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| Names | |
|---|---|
| IUPAC name Methyl (15E)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.02,10.02,13.04,9.010,17]icosa-4,6,8-triene-17-carboxylate | |
Other names
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| Identifiers | |
3D model (JSmol) | |
| ChEMBL | |
| ChemSpider | |
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| Properties | |
| C22H26N2O4 | |
| Molar mass | 382.460 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Corymine, also known asNSC381080, is a naturalalkaloid found inHunteria zeylanica.
This compound acts as aglycine antagonist and could therefore, be classed as aneurotoxin.
Corymine and many otherindole alkaloids can be isolated from parts of theHunteria zeylanica plant.
The plant also contains other similaralkaloids, such as[1]
Corymine and related alkaloids can act asconvulsants.[2]
Tests onXenopus occyte species have shown that corymine can decreaseglycine's action at the inhibitoryglycine receptors.[3] These same tests have revealed that Corymine can reduce the response ofreceptors toGABA,[3] the primary inhibitory neurotransmitter.
Other experiments have shown that corymine can potentiate convulsions induced bystrychnine, a potentglycine antagonist.[4] This was also observed in mice.[5]