C1r along withC1q andC1s form theC1 complex, which is the first component of the serum complement system. C1r is anenzyme that activates C1s to its active form, byproteolytic cleavage.
^Leytus SP, Kurachi K, Sakariassen KS, Davie EW (August 1986). "Nucleotide sequence of the cDNA coding for human complement C1r".Biochemistry.25 (17):4855–63.doi:10.1021/bi00365a020.PMID3021205.
Lee SL, Wallace SL, Barone R, Blum L, Chase PH (1979). "Familial deficiency of two subunits of the first component of complement. C1r and C1s associated with a lupus erythematosus-like disease".Arthritis and Rheumatism.21 (8):958–67.doi:10.1002/art.1780210813.PMID737019.
Ward SL, Ingham KC (January 1992). "A calcium-binding monoclonal antibody that recognizes a non-calcium-binding epitope in the short consensus repeat units (SCRs) of complement C1r".Molecular Immunology.29 (1):83–93.doi:10.1016/0161-5890(92)90160-Y.PMID1370572.
Luo C, Thielens NM, Gagnon J, Gal P, Sarvari M, Tseng Y, Tosi M, Zavodszky P, Arlaud GJ, Schumaker VN (May 1992). "Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex".Biochemistry.31 (17):4254–62.doi:10.1021/bi00132a015.PMID1533159.
Busby TF, Ingham KC (May 1990). "NH2-terminal calcium-binding domain of human complement C1s- mediates the interaction of C1r- with C1q".Biochemistry.29 (19):4613–8.doi:10.1021/bi00471a016.PMID2372546.
Lyons LA, Kamboh MI, Ferrell RE (1989). "Genetic studies of low-abundance human plasma proteins. XI. Linkage analysis and population genetics of the C1S subcomponent of the first complement component".Complement and Inflammation.6 (2):81–7.doi:10.1159/000463078.PMID2541966.
Nguyen VC, Tosi M, Gross MS, Cohen-Haguenauer O, Jegou-Foubert C, de Tand MF, Meo T, Frézal J (April 1988). "Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13".Human Genetics.78 (4):363–8.doi:10.1007/BF00291737.PMID2834284.S2CID30582112.
Leytus SP, Kurachi K, Sakariassen KS, Davie EW (August 1986). "Nucleotide sequence of the cDNA coding for human complement C1r".Biochemistry.25 (17):4855–63.doi:10.1021/bi00365a020.PMID3021205.
Arlaud GJ, Gagnon J (April 1983). "Complete amino acid sequence of the catalytic chain of human complement subcomponent C1-r".Biochemistry.22 (8):1758–64.doi:10.1021/bi00277a003.PMID6303394.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138 (1–2):171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
Nöthen MM, Dewald G (January 1994). "A common amino acid polymorphism in complement component C1R".Human Molecular Genetics.3 (1): 217.doi:10.1093/hmg/3.1.217-a.PMID8162045.
Lacroix M, Rossi V, Gaboriaud C, Chevallier S, Jaquinod M, Thielens NM, Gagnon J, Arlaud GJ (May 1997). "Structure and assembly of the catalytic region of human complement protease C1r: a three-dimensional model based on chemical cross-linking and homology modeling".Biochemistry.36 (21):6270–82.doi:10.1021/bi962719i.PMID9174342.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
Bersch B, Hernandez JF, Marion D, Arlaud GJ (February 1998). "Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family".Biochemistry.37 (5):1204–14.doi:10.1021/bi971851v.PMID9477945.
