Cofilin 1 (non-muscle; n-cofilin), also known asCFL1, is a humangene, part of theADF/cofilin family.
Cofilin is a widely distributed intracellularactin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex fromcytoplasm to nucleus.[5]
One group reports thatreelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration.[6][7]
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^Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S (Aug 1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase".Science.285 (5429):895–8.doi:10.1126/science.285.5429.895.PMID10436159.
Samstag Y, Nebl G (2004). "Interaction of cofilin with the serine phosphatases PP1 and PP2A in normal and neoplastic human T lymphocytes".Adv. Enzyme Regul.43:197–211.doi:10.1016/S0065-2571(02)00031-6.PMID12791392.
van der Steege G, Draaijers TG, Grootscholten PM, Osinga J, Anzevino R, Velonà I, Den Dunnen JT, Scheffer H, Brahe C, van Ommen GJ (1995). "A provisional transcript map of the spinal muscular atrophy (SMA) critical region".Eur. J. Hum. Genet.3 (2):87–95.doi:10.1159/000472281.PMID7552146.S2CID46083524.
Abe H, Nagaoka R, Obinata T (1993). "Cytoplasmic localization and nuclear transport of cofilin in cultured myotubes".Exp. Cell Res.206 (1):1–10.doi:10.1006/excr.1993.1113.PMID8482351.
Gillett GT, Fox MF, Rowe PS, Casimir CM, Povey S (1996). "Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14".Ann. Hum. Genet.60 (Pt 3):201–11.doi:10.1111/j.1469-1809.1996.tb00423.x.PMID8800436.S2CID19565638.
Okada K, Takano-Ohmuro H, Obinata T, Abe H (1996). "Dephosphorylation of cofilin in polymorphonuclear leukocytes derived from peripheral blood".Exp. Cell Res.227 (1):116–22.doi:10.1006/excr.1996.0256.PMID8806458.
Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K (1998). "Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization".Nature.393 (6687):809–12.Bibcode:1998Natur.393..809Y.doi:10.1038/31735.PMID9655398.S2CID4326365.
Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S (1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase".Science.285 (5429):895–8.doi:10.1126/science.285.5429.895.PMID10436159.
Adachi R, Matsui S, Kinoshita M, Nagaishi K, Sasaki H, Kasahara T, Suzuki K (2001). "Nitric oxide induces chemotaxis of neutrophil-like HL-60 cells and translocation of cofilin to plasma membranes".Int. J. Immunopharmacol.22 (11):855–64.doi:10.1016/S0192-0561(00)00045-X.PMID11090694.
