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| Clinical data | |
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| Trade names | Brinaldix |
| AHFS/Drugs.com | International Drug Names |
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| ECHA InfoCard | 100.010.238 |
| Chemical and physical data | |
| Formula | C14H20ClN3O3S |
| Molar mass | 345.84 g·mol−1 |
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Clopamide (trade name Brinaldix) is apiperidinediuretic.[1]
Clopamide is categorised as athiazide-like diuretic and works in similar way as thethiazide diuretics do. It acts in the kidneys, at thedistal convoluted tubule (DCT) of thenephron where it inhibits thesodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption ofsodium chloride, causing an equiosmolar excretion of water along with sodium chloride.