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Cloflubicyne

From Wikipedia, the free encyclopedia
Cloflubicyne
Names
IUPAC name
5,6-dichloro-3,3-bis(trifluoromethyl)bicyclo[2.2.1]heptane-2,2-dicarbonitrile
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C11H6Cl2F6N2/c12-6-4-1-5(7(6)13)9(10(14,15)16,11(17,18)19)8(4,2-20)3-21/h4-7H,1H2
    Key: NTESZNJQNKSALM-UHFFFAOYSA-N
  • C1C2C(C(C1C(C2(C#N)C#N)(C(F)(F)F)C(F)(F)F)Cl)Cl
Properties
C11H6Cl2F6N2
Molar mass351.07 g·mol−1
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Extremely toxic
Lethal dose or concentration (LD, LC):
0.1 mg/kg (intraperitoneal, mice)[1]
0.2 mg/kg (oral, rats)[2]
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

Cloflubicyne is achemical compound which is a chlorinatedderivative ofBIDN. It is an irreversible GABA receptor antagonist with powerfulconvulsant effects.[3][4][5][6]

See also

[edit]

References

[edit]
  1. ^Fetisov, V.I.; Maslov, A.A.; Panarin, V.A.; Trefilov, N.V. (August 1992). "Fluoro-containing 'cage' convulsants: inhibition of gamma-aminobutyric acid induced Cl−currents".Journal of Fluorine Chemistry.58 (2–3): 368.doi:10.1016/S0022-1139(00)80833-7.
  2. ^Middleton, W.J; Bingham, E.M (May 1982). "Fluorine-containing 1,1-dicyanoethylenes: their preparation, diels-alder reactions, and derived norbornenes and norbornanes".Journal of Fluorine Chemistry.20 (3):397–418.Bibcode:1982JFluC..20..397M.doi:10.1016/S0022-1139(00)82232-0.
  3. ^Golovko, A. I.; Sofronov, G. A.; Klyuntina, T. V. (April 1996). "Norbornan, a new irreversible ligand of the GABAA-receptor chloride channels".Bulletin of Experimental Biology and Medicine.121 (4):404–406.doi:10.1007/BF02446741.S2CID 35092380.
  4. ^Golovko, A. I.; Sofronov, G. A.; Klyuntina, T. V.; Suftin, S. G.; Garbuz, L. A. (July 1996). "Norbornane-induced changes in the density of chloride-ion channels in the brain of rodents".Bulletin of Experimental Biology and Medicine.122 (1):660–662.doi:10.1007/BF02446014.S2CID 46036353.
  5. ^Golovko, A. I.; Ivanov, M. B.; Klyuntina, T. V.; Sofronov, G. A.; Sviderskii, O. A.; Shilov, V. V. (January 1997). "Development of increased convulsibility in mice after a single norbornan injection".Bulletin of Experimental Biology and Medicine.123 (1):52–54.doi:10.1007/BF02764378.S2CID 27826524.
  6. ^Golovko, A. I.; Ivanov, M. B.; Sviderskii, O. A.; Sofronov, G. A.; Shilov, V. V. (June 1998). "Mechanisms of kindling induced by norbornan intoxication".Bulletin of Experimental Biology and Medicine.125 (6):579–581.doi:10.1007/BF02445245.S2CID 26207399.
Ionotropic
GABAATooltip γ-Aminobutyric acid A receptor
GABAA-ρTooltip γ-Aminobutyric acid A-rho receptor
Metabotropic
GABABTooltip γ-Aminobutyric acid B receptor
GABA receptor antagonists
GABA synthesis inhibitors
Glycine receptor antagonists
Glutamate receptor agonists
Convulsantbarbiturates
Other
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