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| Trade names | Coldrin, Gentos, Pectolitan, Ulo, Ulone |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Routes of administration | Oral |
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| ECHA InfoCard | 100.011.219 |
| Chemical and physical data | |
| Formula | C17H20ClNO |
| Molar mass | 289.80 g·mol−1 |
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Clofedanol (INN) orchlophedianol (BAN), sold under the brand nameNinjacof among others, is a centrally actingcough suppressant used in the treatment of dry cough. Clofedanol haslocal anesthetic,antispasmodic, andantihistamine properties,[1] and may haveanticholinergic effects at high doses.[2]
Adverse effects may include irritability, drowsiness, nightmares, vertigo, nausea or vomiting, visual disturbances or hallucinations, andurticaria. There are potential interactions with other anticholinergics, CNS depressants, and alcohol.[3]
Unlike many other antitussive drugs such asdextromethorphan, it binds poorly to thesigma-1 receptor.[4]
Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process[5] and its safety and efficacy data are limited. It was formerly sold over-the-counter in the United States under the trade nameUlo, as a syrup with a dosage of 25 mg/5 mL.[6] It is now marketed under the brand name ofNinjacof and others in the U.S.
It is marketed inCanada under the trade nameUlone. GM Pharmaceuticals owns the patents to 113 combinations with Chlophedianol and was the first company to launch the cough suppressant in the United States.[7]
It is sold inJapan as an over-the-counter drug under the name Coldrin.[8] It has been marketed in Germany as Pectolitan and in Spain as Gentos.[9]
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