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| Clinical data | |
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| Trade names | Eumovate |
| Other names | (8S,9R,10S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Routes of administration | topical |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.053.576 |
| Chemical and physical data | |
| Formula | C22H26ClFO4 |
| Molar mass | 408.89 g·mol−1 |
| 3D model (JSmol) | |
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Clobetasone (INN[1]) is acorticosteroid used indermatology, for treating such skin inflammation as seen ineczema,psoriasis and other forms ofdermatitis, andophthalmology. Topical clobetasone butyrate has shown minimal suppression of thehypothalamic–pituitary–adrenal axis.[2]
It is available as clobetasone butyrate under the brand namesEumosone orEumovate[3] both manufactured byGlaxoSmithKline.
Trimovate also containsoxytetracycline, anantibiotic, andnystatin, anantifungal.[4]
Indermatology, topical clobetasone butyrate helps to reduce the itchiness anderythema associated witheczema anddermatitis.[5]
Inophthalmology, clobetasone butyrate 0.1% eye drops have been shown to be safe and effective in the treatment of dry eyes inSjögren syndrome. Sjögren syndrome is an autoimmune disorder that affects the moisture producing glands of the body causing many symptoms including dry eyes.[6] When compared to other corticosteroid eye drops; clobetasone butyrate showed only minimal rises in intraocular pressure. Increased pressure within the eye can lead toglaucoma.[7][8][9]
Side effects associated with clobetasone cream and ointment include: burning, irritation, itching, thinning of the skin, and changes in skin color.[5][10]
The following should not be treated with clobetasone with nystatin and oxytetracycline:
