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| Pronunciation | /kloʊˈbeɪtəsɒl/[1] |
| Trade names | Dermovate, Temovate, Clovate, others |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | Topical |
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| ECHA InfoCard | 100.042.380 |
| Chemical and physical data | |
| Formula | C25H32ClFO5 |
| Molar mass | 466.97 g·mol−1 |
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Clobetasol propionate is acorticosteroid that is used to treat skin conditions such aseczema,contact dermatitis,seborrheic dermatitis, steroid responsive dermatosis, andpsoriasis (including scalp and plaque-type).[7][8] It is applied to the skin as a cream, foam, gel, liquid, solution, ointment, or shampoo.[7][9] Clobetasol propionate is apropionateester of thecorticosteroidclobetasol.[10]
Common side effects include skin irritation, dry skin, redness, pimples, andtelangiectasia.[7] Serious side effects may includeadrenal suppression,allergic reactions,cellulitis, andCushing's syndrome.[7] Use inpregnancy andbreastfeeding is of unclear safety.[11] Clobetasol is believed to work by activatingsteroid receptors.[7]
Clobetasol propionate was patented in 1968 and came into medical use in 1978.[12] It is available as ageneric medication.[9] In 2023, it was the 129th most commonly prescribed medication in the United States, with more than 4 million prescriptions.[13][14]
Clobetasol propionate is used for the treatment of various skin disorders includingeczema,herpes labialis,[15]psoriasis, andlichen sclerosus. It is also used to treat severalauto-immune diseases includingalopecia areata,lichen planus (auto immune skin nodules), andmycosis fungoides (T-cell skin lymphoma). It is used as a first-line treatment for both acute and chronicGVHD of the skin.[16]
Clobetasol propionate is used cosmetically for skin whitening, although this use is controversial. The USFood and Drug Administration has not approved it for that purpose, and sales without a prescription are illegal in the US. Nonetheless, skin-whitening creams containing this ingredient can sometimes be found in beauty supply stores in New York City and on the internet. It is also sold internationally and does not require a prescription in some countries. Whitening creams with clobetasol propionate, such as Hyprogel, can make skin thin and easily bruised, with visible capillaries, and acne. It can also lead to hypertension, elevated blood sugar, suppression of the body's natural steroids, and stretch marks, which may be permanent.[17]
Clobetasol propionate is, along with mercury andhydroquinone, "amongst the most toxic, the latter in higher concentrations, and most used agents in lightening products." Many products sold illegally have higher concentrations of clobetasol propionate than is permitted for prescription drugs.[18]
Clobetasol 0.05% is considered a member of the "super-high potency" group of topical corticosteroids out of seven total groups in the United States classification system of topical corticosteroids.[19][8]
Clobetasol propionate is marketed and sold worldwide under many names, including Clobex, Clob-x, Clovate, Clobet, Clonovate, Cormax, Haloderm, Pentasol, Cosvate, Clop, Propysalic, Temovate, Dermovate, Olux, ClobaDerm, Tenovate, Dermatovate, Butavate, Movate, Novate, Salac, Powercort, Lotasbat, Kloderma, Lemonvate, Clobesol, Dovate, Delor, Psovate, Clinoderm [Thailand] and Skineal.
