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Clobenpropit

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Chemical compound

Pharmaceutical compound

Clobenpropit
Clinical data

ATC code	None
Legal status
Legal status	US: Investigational New Drug
Identifiers
IUPAC name N'-[(4-chlorophenyl)methyl]-1-[3-(3H-imidazol-4-yl)propylsulfanyl]formamidine
CAS Number	145231-45-4
PubChemCID	2790
IUPHAR/BPS	1223
ChemSpider	2688
UNII	RKU631JF4H
ChEMBL	ChEMBL14690
CompTox Dashboard(EPA)	DTXSID3043738
Chemical and physical data
Formula	C₁₄H₁₇ClN₄S
Molar mass	308.83 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1=CC(=CC=C1CN=C(N)SCCCC2=CN=CN2)Cl

Clobenpropit is ahistamine H₃ receptor antagonist.^[1] It hasneuroprotective effects via stimulation ofGABA release in brain cellsin vitro.^[2]

^Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels inXenopus oocytes".European Journal of Pharmacology.567 (3):206–210.doi:10.1016/j.ejphar.2007.04.032.PMID 17537431.
^Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z (2007). "The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons".European Journal of Pharmacology.563 (1–3):117–123.doi:10.1016/j.ejphar.2007.01.069.PMID 17350613.

Agonists

Antagonists

Agonists	Amthamine Betazole Dimaprit Histamine HTMT Impromidine L-Histidine UR-AK49
Antagonists	Bisfentidine Burimamide Cimetidine Dalcotidine Donetidine Ebrotidine Etintidine Famotidine Isolamtidine Lafutidine Lamtidine Lavoltidine (loxtidine) Lupitidine Metiamide Mifentidine Niperotidine Nizatidine Osutidine Oxmetidine Pibutidine Quisultazine (quisultidine) Ramixotidine Ranitidine Roxatidine Sufotidine Tiotidine Tuvatidine Venritidine Xaltidine Zolantidine

Agonists	α-Methylhistamine BP 2.94 Cipralisant (GT-2331) GT-2203 (VUF-5296) Histamine Imetit Immepip Immethridine (BP-1-5375) L-Histidine Methimepip Proxyfan SCH-50971 VUF-5297
Antagonists	A-349821 A-423579 ABT-239 ABT-652 AZD5213 Bavisant Betahistine Burimamide Ciproxifan Clobenpropit Conessine Enerisant GSK-189254 Impentamine Iodophenpropit Irdabisant JNJ-5207852 NNC 38-1049 PF-03654746 Pitolisant SCH-79687 Thioperamide VUF-5681

Agonists	4-Methylhistamine α-Methylhistamine Histamine L-Histidine OUP-16 VUF-8430
Antagonists	JNJ-7777120 Mianserin Seliforant Thioperamide Toreforant VUF-6002

See also: Receptor/signaling modulators; Monoamine metabolism modulators; Monoamine reuptake inhibitors

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