Clive McCay | |
|---|---|
| Born | (1898-03-21)21 March 1898 |
| Died | 8 June 1967(1967-06-08) (aged 69) |
| Known for | calorie restrictionlife extension |
| Scientific career | |
| Institutions | Cornell University |
Clive Maine McCay (21 March 1898 – 8 June 1967) was an Americanbiochemist,nutritionist andgerontologist.
McCay was professor ofanimal husbandry atCornell University from 1927 to 1963. His main interest was the influence of nutrition on aging.[1] He is best known for his work in proving thatcaloric restriction increases the life span of rats, which is seen as seminal in triggering further research and experiments in the field of nutrition and longevity.[2] Scientists are still trying to understand the connection between caloric restriction and longevity.
Following his discovery between a low calorie diet and longevity, McCay played a prominent role in the development of nutritionally-sound rations duringWorld War II, and the creation ofCornell Bread, a type of highprotein, highvitaminbread meant to echo the same high protein vitamin meal he fed to his mice in longevity experiments.
Another of McCay's important contributions was the first work inheterochronic parabiosis: the joining of the circulatory systems of a young and an old animal, which leads to rejuvenating effects on the tissues of the old animal and degenerative changes in the young's, thus demonstrating the role of systemic factors in aging.[3][4] Limited work with this paradigm by others continued into the early 1970s before languishing, until it was finally taken up again by researchers atStanford University and theUniversity of California at Berkeley in the mid-2000s.[3][5]
His further research centered on canine nutrition, andfluoride and its use in water treatment.[4] A 1957 study on fluoridation showed that low levels (1-10 ppm) of sodium fluoride added to the drinking water of rats did not have carie-protective effects.[6]
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