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Clebopride

From Wikipedia, the free encyclopedia
Dopamine antagonist drug
Pharmaceutical compound
Clebopride
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 4-amino-N-(1-benzylpiperidin-4-yl)-5-chloro-
    2-methoxybenzamide
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.054.424Edit this at Wikidata
Chemical and physical data
FormulaC20H24ClN3O2
Molar mass373.88 g·mol−1
3D model (JSmol)
  • Clc1cc(c(OC)cc1N)C(=O)NC3CCN(Cc2ccccc2)CC3
  • InChI=1S/C20H24ClN3O2/c1-26-19-12-18(22)17(21)11-16(19)20(25)23-15-7-9-24(10-8-15)13-14-5-3-2-4-6-14/h2-6,11-12,15H,7-10,13,22H2,1H3,(H,23,25) checkY
  • Key:BVPWJMCABCPUQY-UHFFFAOYSA-N checkY
  (verify)

Clebopride is adopamine antagonist drug withantiemetic andprokinetic properties used to treat functional gastrointestinal disorders. Chemically, it is asubstitutedbenzamide, closely related tometoclopramide.

A small Spanish study found that moreadverse reactions are reported with clebopride than with metoclopramide, particularlyextrapyramidal symptoms.[1]

References

[edit]
  1. ^Cuena Boy R, Maciá Martínez MA (March 1998). "[Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]".Atencion Primaria (in Spanish).21 (5):289–95.PMID 9608114.Free full textArchived 2018-11-01 at theWayback Machine
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists
Drugs for
functional
bowel
disorders
Antimuscarinics
Tertiary
amino group
Quaternary
ammonium

compounds
Phosphodiesterase
inhibitors
Acting on
serotonin receptors
Other
Belladonna
and derivatives
(antimuscarinics)
Propulsives
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