Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

Cinanserin

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Cinanserin
Clinical data
Other namesSQ-10643; SQ10643; NSC-125717; NSC125717
Drug classSerotonin5-HT2 receptorantagonist;Serotonin 5-HT2A receptor antagonist
ATC code
  • None
Identifiers
  • (2E)-N-(2-{[3-(dimethylamino)propyl]thio}phenyl)-3-phenylacrylamide
CAS Number
PubChemCID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.220.552Edit this at Wikidata
Chemical and physical data
FormulaC20H24N2OS
Molar mass340.49 g·mol−1
3D model (JSmol)
  • CN(C)CCCSC1=CC=CC=C1NC(=O)\C=C\C2=CC=CC=C2
  • InChI=1S/C20H24N2OS/c1-22(2)15-8-16-24-19-12-7-6-11-18(19)21-20(23)14-13-17-9-4-3-5-10-17/h3-7,9-14H,8,15-16H2,1-2H3,(H,21,23)/b14-13+ ☒N
  • Key:RSUVYMGADVXGOU-BUHFOSPRSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Cinanserin (INNTooltip International Nonproprietary Name; developmental code nameSQ-10643) is aserotonin5-HT2A and5-HT2C receptorantagonist which was discovered in the 1960s and was never marketed.[1][2][3] It has about 50-fold higheraffinity for the 5-HT2A receptor than for 5-HT2C, and very low affinity for5-HT1 receptors.[3] The drug also inhibits the3C-like protease ofSARS-CoV-1[4] andSARS-CoV-2,[5] but with much lower affinity.

See also

[edit]

References

[edit]
  1. ^Elks, J. (14 November 2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer.ISBN 978-1-4757-2085-3. Retrieved17 January 2026.
  2. ^Neuman RS, Zebrowska G (December 1992). "Serotonin (5-HT2) receptor mediated enhancement of cortical unit activity".Canadian Journal of Physiology and Pharmacology.70 (12):1604–9.doi:10.1139/y92-230.PMID 1301238.
  3. ^abGlennon RA (January 1987). "Central serotonin receptors as targets for drug research".J Med Chem.30 (1):1–12.doi:10.1021/jm00384a001.PMID 3543362.Table II. Affinities of Selected Phenalkylamines for 5-HT1 and 5-HT2 Binding Sites
  4. ^Chen L, Gui C, Luo X, Yang Q, Günther S, Scandella E, et al. (June 2005)."Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro".Journal of Virology.79 (11):7095–103.doi:10.1128/JVI.79.11.7095-7103.2005.PMC 1112131.PMID 15890949.
  5. ^Jin Z, Du X, Xu Y, Deng Y, Liu M, Zhao Y, Zhang B, Li X, Zhang L, Peng C, Duan Y, Yu J, Wang L, Yang K, Liu F, Jiang R, Yang X, You T, Liu X, Yang X, Bai F, Liu H, Liu X, Guddat LW, Xu W, Xiao G, Qin C, Shi Z, Jiang H, Rao Z, Yang H (June 2020)."Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors".Nature.582 (7811):289–293.doi:10.1038/s41586-020-2223-y.PMID 32272481.Cinanserin is an inhibitor of SARS-CoV-2 Mpro.
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT3–7
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
Stub icon

Thisdrug article relating to thenervous system is astub. You can help Wikipedia byadding missing information.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Cinanserin&oldid=1333443278"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2026 Movatter.jp