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Cimlanod

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Cimlanod
Legal status
Legal status
  • Investigational
Identifiers
  • N-Hydroxy-5-methylfuran-2-sulfonamide
CAS Number
PubChemCID
DrugBank
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC5H7NO4S
Molar mass177.17 g·mol−1
3D model (JSmol)
  • CC1=CC=C(O1)S(=O)(=O)NO

Cimlanod (development codesCXL-1427 andBMS-986231) is an experimental drug for the treatment ofacute decompensated heart failure. It was discovered by Cardioxyl Pharmaceuticals, which was acquired byBristol-Myers Squibb. It is aprecursor ofnitroxyl.[1]

Cimlanod is aprodrug of CXL-1020.[2]

A preliminary study showed efficacy in patients with class III and IV heart failure.[3] A phase II clinical trial was completed in 2016.[4]

References

[edit]
  1. ^"BMS 986231".AdisInsight. Springer Nature Switzerland AG. Retrieved2017-05-22.Alternative Names: BMS-986231; CXL 1427; HNO Donor
  2. ^"CXL 1020".AdisInsight. Springer Nature Switzerland AG. Retrieved2017-05-22.
  3. ^Zoler ML (22 May 2016)."Nitroxyl prodrug shows promise in acute heart failure".
  4. ^Clinical trial numberNCT02157506 for "A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure" atClinicalTrials.gov
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