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Ciladopa

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Ciladopa
Clinical data
Other namesAY-27,110
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • 2-{4-[(2S)-2-(3,4-dimethoxyphenyl)-2-hydroxyethyl]piperazin-1-yl}cyclohepta-2,4,6-trien-1-one
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC21H26N2O4
Molar mass370.449 g·mol−1
3D model (JSmol)
  • O=C3/C=C\C=C/C=C3/N2CCN(C[C@@H](O)c1ccc(OC)c(OC)c1)CC2

Ciladopa (developmental code nameAY-27,110) is adopamine agonist with a similarchemical structure todopamine.[1] It was under investigation as anantiparkinsonian agent but was discontinued due to concerns oftumorogenesis in rodents.[2][3][4][5]

References

[edit]
  1. ^Voith K (1985). "The comparative long-term effects of ciladopa (AY-27,110), a chemically novel dopaminergic agonist, in 6-OHDA-lesioned and intact rats".Psychopharmacology.85 (4):405–9.doi:10.1007/BF00429654.PMID 3927334.S2CID 1573473.
  2. ^Koller WC, Fields JZ, Gordon JH, Perlow MJ (September 1986). "Evaluation of ciladopa hydrochloride as a potential anti-Parkinson drug".Neuropharmacology.25 (9):973–9.doi:10.1016/0028-3908(86)90190-5.PMID 3774130.S2CID 19175441.
  3. ^Weiner WJ, Factor SA, Sanchez-Ramos J, Berger J (1987). "A double-blind evaluation of ciladopa in Parkinson's disease".Movement Disorders.2 (3):211–7.doi:10.1002/mds.870020308.PMID 3332914.S2CID 31784301.
  4. ^Lieberman A, Gopinathan G, Neophytides A, Pasternack P, Goldstein M (May 1987). "Advanced Parkinson's disease: use of partial dopamine agonist, ciladopa".Neurology.37 (5):863–5.doi:10.1212/wnl.37.5.863.PMID 3574692.S2CID 25273606.
  5. ^Lang AE (August 1987)."Update on dopamine agonists in Parkinson's disease: "beyond bromocriptine"".The Canadian Journal of Neurological Sciences.14 (3 Suppl):474–82.doi:10.1017/s031716710003794x.PMID 3315148.
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