Professor of Bioinformatics
Christine Anne Orengo FRS Professor ofBioinformatics atUniversity College London (UCL)[ 2] [ 6] [ 7] [ 8] protein structure , particularly theCATH database .[ 5] [ 9] president of theInternational Society for Computational Biology (ISCB), the first woman to do so in the history of the society.[ 10]
Orengo studiedChemical Physics at theUniversity of Bristol where she was awarded aBachelor of Science degree in 1976.[ 11] University of Aberdeen where she was awarded aMaster of Science degree inMedical Physics in 1977 for research on the disruption ofiron metabolism inlaboratory rats withYoshida sarcomas .[ 12] PhD for research on theredox properties ofhaem inproteins in 1984 from UCL.[ 13]
Career and research [ edit ] Following her PhD, Orengo worked in industry as Chief Chemist for FCI International, Brussels and mathematical modeller for Humphreys & Glasgow in London.[ 11] postdoctoral researcher at theNational Institute for Medical Research (NIMR) inMill Hill where she worked until 1990.[ 9] biochemistry andmolecular biology at UCL and in 1995 and was awarded aMedical Research Council (MRC) seniorfellowship in Bioinformatics. She was promoted to Professor of Bioinformatics in 2002.[ 9]
Orengo's research analyses genes, proteins and biological systems usingcomputational methods toclassify proteins into evolutionary families . Her research has been funded by the Medical Research Council and theBiotechnology and Biological Sciences Research Council (BBSRC).[ 14]
Orengo is co-editor withDavid Jones andJanet Thornton of the textbookBioinformatics: Genes, Proteins and Computers .[ 15] [update] Google Scholar [ 2] Scopus [ 6] Nature [ 16] Nucleic Acids Research ,[ 17] [ 18] Structure [ 5] Journal of Molecular Biology [ 19] [ 20] Camilla Pang ,[ 3] [ 21] [ 22] [ 23]
Orengo was elected a member of theEuropean Molecular Biology Organization (EMBO) in 2014 and aFellow of the Royal Society (FRS) in 2019.[ 1] [ 24] [ 25]
^a b Anon (2015)."The EMBO Pocket Directory" (PDF) . Heidelberg: European Molecular Biology Organization. Archived fromthe original (PDF) on 16 March 2015. ^a b c Christine Orengo publications indexed byGoogle Scholar ^a b Pang, Camilla Sih Mai (2018).Developing a computational approach to investigate the impacts of disease-causing mutations on protein function ucl.ac.uk (PhD thesis). University College London.OCLC 1063745930 .EThOS uk.bl.ethos.747644 . ^ Christine Orengo atLibrary of Congress ^a b c Orengo, C. A.; Michie, A. D.; Jones, S.; Jones, D. T.; Swindells, M. B.;Thornton, J. M. (1997)."CATH – a hierarchic classification of protein domain structures" .Structure .5 (8):1093– 1109.doi :10.1016/S0969-2126(97)00260-8 PMID 9309224 . ^a b Christine Orengo publications indexed by theScopus bibliographic database.(subscription required) ^ Christine Orengo publications fromEurope PubMed Central ^ Christine Orengo'sORCID 0000-0002-7141-8936 ^a b c "Professor Christine Orengo" . University College London. Archived fromthe original on 19 May 2015.^ "Officers and Directors" . Iscb.org. Retrieved29 February 2020 .^a b "GeCIP Detailed Research Plan Form" (PDF) .Genomics England . Retrieved27 April 2021 .^ Orengo, Christine Anne (1977).Disruption of iron metabolism in rats with Yoshida sarcomas (MSc thesis). University of Aberdeen.OCLC 646442339 . ^ Orengo, Christine Anne (1984).A study of the redox properties of haem in proteins and model systems london.ac.uk (PhD thesis). University College London.OCLC 927065626 . ^ "UK Government research grants awarded to Christine Orengo" .Research Councils UK . 27 November 2015. Archived fromthe original on 27 November 2015.^ Bioinformatics: Genes, Proteins and Computers . BIOS. 2003.ISBN 1859960545 ^ Orengo, Christine Anne; Jones, David T.; Thornton, Janet M. (1994). "Protein superfamilles and domain superfolds".Nature .372 (6507):631– 634.Bibcode :1994Natur.372..631O .doi :10.1038/372631a0 .ISSN 0028-0836 .PMID 7990952 .S2CID 4330359 . ^ Hunter, S.;Apweiler, R. ;Attwood, T. ;Bairoch, A. ;Bateman, A. ; Binns, D.;Bork, P. ; Das, U.; Daugherty, L.; Duquenne, L.; Finn, R. D.;Gough, J. ; Haft, D.; Hulo, N.; Kahn, D.; Kelly, E.; Laugraud, A.; Letunic, I.; Lonsdale, D.; Lopez, R.; Madera, M.; Maslen, J.; McAnulla, C.; McDowall, J.; Mistry, J.; Mitchell, A.; Mulder, N.; Natale, D.; Orengo, C.; Quinn, A. F. (January 2009)."InterPro: the integrative protein signature database" .Nucleic Acids Research 37 (Database issue):D211 – D215 .doi :10.1093/nar/gkn785 .ISSN 0305-1048 .PMC 2686546 PMID 18940856 . ^ Hunter, S.; Jones, P.; Mitchell, A.; Apweiler, R.; Attwood, T. K.; Bateman, A.; Bernard, T.; Binns, D.; Bork, P.; Burge, S.; De Castro, E.; Coggill, P.; Corbett, M.; Das, U.; Daugherty, L.; Duquenne, L.; Finn, R. D.; Fraser, M.; Gough, J.; Haft, D.; Hulo, N.; Kahn, D.; Kelly, E.; Letunic, I.; Lonsdale, D.; Lopez, R.; Madera, M.; Maslen, J.; McAnulla, C.; McDowall, J. (2011)."InterPro in 2011: New developments in the family and domain prediction database" .Nucleic Acids Research .40 (Database issue):D306 – D312 .doi :10.1093/nar/gkr948 .PMC 3245097 PMID 22096229 . ^ Todd, Annabel E; Orengo, Christine A; Thornton, Janet M (2001)."Evolution of function in protein superfamilies, from a structural perspective" .Journal of Molecular Biology .307 (4):1113– 1143.doi :10.1006/jmbi.2001.4513 ISSN 0022-2836 .PMID 11286560 .S2CID 14355820 . ^ Taylor, William R.; Orengo, Christine Anne (1989). "Protein structure alignment".Journal of Molecular Biology .208 (1):1– 22.doi :10.1016/0022-2836(89)90084-3 .ISSN 0022-2836 .PMID 2769748 . ^ Lehtinen, Sonja; Bähler, Jürg; Orengo, Christine (2015)."Co-Expression Network Models Suggest that Stress Increases Tolerance to Mutations" .Scientific Reports .5 : 16726.Bibcode :2015NatSR...516726L .doi :10.1038/srep16726 .ISSN 2045-2322 .PMC 4644955 PMID 26568486 . ^ "Orengo lab alumni" . University College London. 22 May 2015. Archived fromthe original on 22 May 2015.^ Sillitoe, Ian (2003).Consensus templates for protein structure recognition london.ac.uk (PhD thesis). University College London.OCLC 500146824 .EThOS 404942 . ^ "EMBO member: Christine Anne Orengo" . Heidelberg: EMBO. Archived fromthe original on 6 December 2015.^ Anon (2019)."Professor Christine Orengo FRS" .royalsociety.org . London. Archived fromthe original on 24 April 2019. “All text published under the heading 'Biography' on Fellow profile pages is available underCreative Commons Attribution 4.0 International License .” --Royal Society Terms, conditions and policies at theWayback Machine (archived 2016-11-11)
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