 | |
| Names | |
|---|---|
| IUPAC name [(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate | |
| Other names Cholest-5-en-3β-ol sulfate | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| UNII | |
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| |
| Properties | |
| C27H46O4S | |
| Molar mass | 466.72 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Cholesterol sulfate, orcholest-5-en-3β-ol sulfate, is anendogenoussteroid and the C3βsulfateester ofcholesterol.[1][2] It is formed from cholesterol bysteroid sulfotransferases (SSTs) such asSULT2B1b (also known as cholesterol sulfotransferase)[2] and is converted back into cholesterol bysteroid sulfatase (STS).[1] Accumulation of cholesterol sulfate in theskin is implicated in thepathophysiology ofX-linked ichthyosis, acongenital disorder in which STS is non-functional and the body cannot convert cholesterol sulfate back into cholesterol.[1][2]
