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Chlorphenoxamine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Chlorphenoxamine
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral, topical
ATC code
Pharmacokinetic data
BioavailabilityWell absorbed
MetabolismLikelyliver
Excretionkidney
Identifiers
  • {2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}dimethylamine
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.115.538Edit this at Wikidata
Chemical and physical data
FormulaC18H22ClNO
Molar mass303.83 g·mol−1
3D model (JSmol)
  • Clc1ccc(cc1)C(OCCN(C)C)(c2ccccc2)C
  • InChI=1S/C18H22ClNO/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16/h4-12H,13-14H2,1-3H3 checkY
  • Key:KKHPNPMTPORSQE-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Chlorphenoxamine (Phenoxene) is anantihistamine andanticholinergic used as anantipruritic[1] andantiparkinsonian[2] agent. It is an analog ofdiphenhydramine.[3]

References

[edit]
  1. ^Bazex A, Dupre A, Christol B (1963). "[Trial treatment of urticaria with chlorphenoxamine]".Clinique.58:447–50.PMID 13967113.
  2. ^Uldall PR, Walton JN, Newell DJ (June 1961)."Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial".British Medical Journal.1 (5240):1649–52.doi:10.1136/bmj.1.5240.1649.PMC 1954253.PMID 13779077.
  3. ^Arnold H, Brock N, Kuhas E, Lorenz D (January 1954). "Beitrag Zur Wirkung Von Antihistamin-Substanzen. 1. Chemische Konstitution Und Pharmakologische Wirkung in Der Gruppe Der Basischen Benzhydrylaether" [Contribution to the Effect Of Antihistamine Substances. 1. Chemical constitution and pharmacological activity in the group of basic benzhydrylethers].Arzneimittel-Forschung [Drug Research] (in German).4 (3):189–94.PMID 13159698.
Antihistamines fortopical use
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Fortopical use
mAChRsTooltip Muscarinic acetylcholine receptors
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(andprodrugs)
nAChRsTooltip Nicotinic acetylcholine receptors
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(andPAMsTooltip positive allosteric modulators)
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(andNAMsTooltip negative allosteric modulators)
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(andprodrugs)
H1
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H2
Agonists
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H3
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H4
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