 | |
| Names | |
|---|---|
| IUPAC name 1-(4-Chlorophenyl)-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane | |
| Other names RS-150 Caswell No. 213B 1-(p-Chlorophenyl)silatrane 5-(p-Chlorophenyl)silatrane 5-(4-Chlorophenyl)silatrane | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider | |
| ECHA InfoCard | 100.252.129 |
| UNII | |
| |
| |
| Properties | |
| C12H16ClNO3Si | |
| Molar mass | 285.8 g/mol |
| Appearance | odorless, white powder[1] |
| Melting point | 230-235 °C[1] |
| <0.2 g/L[1] | |
| Solubility in Chloroform, Benzene | soluble[1] |
| Hazards | |
| Occupational safety and health (OHS/OSH): | |
Main hazards | Extremely toxic |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose) | 1-4 mg/kg (rats, oral)[1] 3000 mg/kg (rats, dermal)[1] 0.9-2.0 mg/kg (mice, oral)[1] |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
1-(4-Chlorophenyl)silatrane is an extremely toxic[2]organosilicon compound which was developed byM&T Chemicals as a single-doserodenticide.[1] It was never registered as rodenticide,[2] except for experimental use.[1] 1-(4-Chlorophenyl)silatrane was one of the chemicals studied in theProject Coast.[3][4]
1-(4-Chlorophenyl)silatrane is aGABA receptor antagonist[5] and it destroys nervous functions in the central nervous system of vertebrates, primarily in the brain and possibly in the brain stem.[6][7][8] It's a rapid actingconvulsant, causing convulsions within 1 minute in mice and rats. Death occurred within 5 minutes.[9] It is therefore likely to inducepoison shyness.[2] In field trials, it was less effective thanzinc phosphide against wild rats.[10]
