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Chlorisondamine

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From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

Chlorisondamine
Clinical data

ATC code	None
Identifiers
IUPAC name Trimethyl-[2-(4,5,6,7-tetrachloro-2-methyl-isoindolin-2-ium-2-yl)ethyl]ammonium dichloride
CAS Number	7701-62-4^Y
PubChemCID	6243
ChemSpider	6008^Y
UNII	JD3M24F66I
ChEMBL	ChEMBL2104531^N
CompTox Dashboard(EPA)	DTXSID0048395
Chemical and physical data
Formula	C₁₄H₂₀Cl₆N₂
Molar mass	429.03 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES [Cl-].[Cl-].Clc1c2c(c(Cl)c(Cl)c1Cl)C[N+](C2)(C)CC[N+](C)(C)C
InChI InChI=1S/C14H20Cl4N2/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15/h5-8H2,1-4H3/q+2^Y Key:IXWDUZLHWJKVPX-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Chlorisondamine is anicotinic acetylcholine receptor antagonist that produces bothneuronal andganglionic blockade.

Chlorisondamine has been shown to form noncovalent complexes with various biomolecules includingsphingomyelin and other associatedglycolipids.^[1]^[2]^[3]

References

[edit]

^Woods AS, Moyer SC, Wang HY, Wise RA (2003). "Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor".Journal of Proteome Research.2 (2):207–12.doi:10.1021/pr025578h.PMID 12716135.
^Jackson SN, Wang HY, Woods AS, Ugarov M, Egan T, Schultz JA (February 2005)."Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS".Journal of the American Society for Mass Spectrometry.16 (2):133–8.Bibcode:2005JASMS..16..133J.doi:10.1016/j.jasms.2004.10.002.PMID 15694763.S2CID 5894935.
^Woods AS, Ugarov M, Egan T, Koomen J, Gillig KJ, Fuhrer K, Gonin M, Schultz JA (April 2004). "Lipid/peptide/nucleotide separation with MALDI-ion mobility-TOF MS".Analytical Chemistry.76 (8):2187–95.doi:10.1021/ac035376k.PMID 15080727.

Sympatholytic (and closely related)antihypertensives (C02)

Sympatholytics
(antagonizeα-adrenergic
vasoconstriction)

Central

α₂-Adrenergic receptor agonists	Clonidine Guanabenz Guanfacine Guanoxabenz Methyldopa^# Tiamenidine^‡
Adrenergic release inhibitors	Bethanidine Bretylium Debrisoquine Guanadrel Guanazodine Guancydine Guanethidine Guanoclor Guanoxan
Imidazoline receptor agonists	Moxonidine Rilmenidine Tolonidine
Ganglion-blocking/nicotinic antagonists	Hexamethonium^‡ Mecamylamine Pentolinium Trimethaphan

Peripheral

Indirect

Monoamine oxidase inhibitors	Pargyline^‡
VMAT inhibitors	Bietaserpine Deserpidine Methoserpidine Reserpine Syrosingopine
Tyrosine hydroxylase inhibitors	Metirosine

Direct

α₁-Adrenergic receptor blockers	Doxazosin Ketanserin Indoramin Prazosin Trimazosin Urapidil
Non-selective α-adrenergic receptor blockers	Phentolamine

Otherantagonists

Serotonin receptor antagonists	Ketanserin Lidanserin
Endothelin receptor antagonists (for PHTooltip Pulmonary hypertension)	dual (Aprocitentan,Bosentan,Macitentan (+tadalafil),Riociguat) selective (Ambrisentan (+tadalafil),Sitaxentan,Sotatercept)