Charles M. Rice | |
|---|---|
.jpg) Rice at 2024 Nobel Week | |
| Born | Charles Moen Rice (1952-08-25)August 25, 1952 (age 73) Sacramento, California, U.S. |
| Alma mater | University of California, Davis (BS) California Institute of Technology (MS,PhD) |
| Awards | |
| Scientific career | |
| Institutions | |
| Thesis | Studies on the Structural Proteins ofSindbis Virus (1981) |
| Doctoral advisor | James Strauss |
| Website | www |
Charles Moen Rice (born August 25, 1952) is an American virologist and Nobel Prize laureate whose main area of research is thehepatitis C virus. He is a professor of virology at theRockefeller University and an adjunct professor atCornell University andWashington University School of Medicine. At the time of the award he was a faculty at Rockefeller.
Rice is a Fellow of theAmerican Association for the Advancement of Science, member of theNational Academy of Sciences and was president of theAmerican Society for Virology from 2002 to 2003. He received the 2016Lasker-DeBakey Clinical Medical Research Award, jointly withRalf F. W. Bartenschlager andMichael J. Sofia.[1][2] Along withMichael Houghton andHarvey J. Alter, he was awarded the2020 Nobel Prize in Physiology or Medicine "for the discovery ofHepatitis C virus."[3][4]
Charles Moen Rice was born on August 25, 1952, inSacramento, California.[5][6]
Rice graduatedPhi Beta Kappa[7] with aB.S. inzoology fromUniversity of California, Davis, in 1974. In 1981, he received hisPh.D. inbiochemistry from theCalifornia Institute of Technology, where he studiedRNA viruses in thelaboratory ofJames Strauss.[8] He remained at Caltech for four years to dopostdoctoral research.[9][10]
After his postdoctoral work, Rice moved with his research group to theWashington University School of Medicine in 1986, where he remained until 2001.[3]
Rice has been the Maurice R. and Corinne P. Greenberg Professor at Rockefeller University since 2001. He is also an adjunct professor at Washington University School of Medicine andCornell University. He has served on committees for theFood and Drug Administration,National Institutes of Health, andWorld Health Organization.[9]
He was the editor ofJournal of Experimental Medicine from 2003 to 2007,Journal of Virology from 2003 to 2008, andPLoS Pathogens from 2005 to present. He has been an author of over 400 peer-reviewed publications.[9]
While at Caltech, he was involved in researching the genome ofSindbis virus and the establishment offlaviviruses as their own family of viruses. The strain ofyellow fever virus he used for this work was eventually used for the development of theyellow fever vaccine. While exploring Sindbis virus atWashington University in St. Louis, Rice described how he produced infectious flavivirusRNA in the laboratory in a 1989 paper published inThe New Biologist. The paper attracted the attention ofStephen Feinstone who was studyinghepatitis C virus and suggested that Rice use the technique to develop a vaccine forhepatitis C. In 1997, Rice cultured the first infectious clone of hepatitis C virus for use in studies on chimpanzees in whom the virus was also endemic. In 2005, Rice was also part of a team that showed that a strain of an acute form of the virus identified in a human patient can be forced to replicate in a laboratory setting. Rice's contribution to hepatitis C research has earned him many awards.[6]
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