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Ceronapril

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Chemical compound

Pharmaceutical compound

Ceronapril
Clinical data

AHFS/Drugs.com	Monograph
ATC code	C09AA09 (WHO)
Identifiers
IUPAC name 1-[(2S)-6-Amino-2-hydroxyhexanoyl]-L-proline, hydrogen (4-phenyl-butyl)phosphonate
CAS Number	111223-26-8
PubChemCID	189729
ChemSpider	164789
UNII	X3MM60SOVP
KEGG	D03440
CompTox Dashboard(EPA)	DTXSID80891418
Chemical and physical data
Formula	C₃₀H₄₆NO₇P
Molar mass	563.672 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1C[C@H](N(C1)C(=O)[C@H](CCCCN)OP(=O)(CCCCC2=CC=CC=C2)O)C(=O)O
InChI InChI=1S/C30H46NO7P/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35)/t25-,26+,30?,39-/m1/s1^Y Key:BIDNLKIUORFRQP-YYTCENNOSA-N^Y

Ceronapril (INN,^[1] proposed trade namesCeranapril,Novopril) is a phosphonateACE inhibitor^[2] that was never marketed.^{[citation needed]}

^"International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names (Rec. INN): List 31"(PDF). World Health Organization. p. 4. Retrieved2 March 2017.
^Tu JI, Brennan J, Stouffer B, Mantha S, Turabi N, Tsay HM (June 1992). "Radioimmunoassay for ceronapril, a new angiotensin-converting enzyme inhibitor, and its application to a pharmacokinetic study in healthy male volunteers".Therapeutic Drug Monitoring.14 (3):209–19.doi:10.1097/00007691-199206000-00007.PMID 1412607.S2CID 23854785.

v t e Antihypertensive drugs acting on therenin–angiotensin system (C09)
ACE inhibitors ("-pril")	Sulfhydryl-containing:Captopril Rentiapril Zofenopril (+nebivolol) Dicarboxylate-containing:Enalapril^# (+lercanidipine,+nitrendipine) Benazepril (+amlodipine,+pimobendan) Cilazapril Delapril (+manidipine) Imidapril Lisinopril (+amlodipine,+HCT) Moexipril Perindopril (+amlodipine,+bisoprolol,+indapamide,+amlodipine and indapamide,+bisoprolol and amlodipine,+bisoprolol, amlodipine, and indapamide) Quinapril (+HCT) Ramipril (+amlodipine,+amlodipine and HCT,+bisoprolol,+felodipine) Spirapril Temocapril Trandolapril (+verapamil) Phosphonate-containing:Ceronapril Fosinopril (+HCT) Other/ungrouped:Alacepril
AIIRAs ("-sartan")	Azilsartan Candesartan (+amlodipine,+amlodipine and HCT) Eprosartan Fimasartan Irbesartan (+amlodipine,+amlodipine and HCT,+HCT) Losartan (+amlodipine,+HCT) Olmesartan (+amlodipine,+amlodipine and HCT,+HCT) Tasosartan^§ Telmisartan (+amlodipine,+amlodipine and HCT,+HCT) Valsartan (+aliskiren,+amlodipine,+amlodipine and HCT,+HCT,+lercanidipine,+nebivolol,+sacubitril)
Renin inhibitors ("-kiren")	Aliskiren (+amlodipine,+HCT,+amlodipine and HCT) Remikiren^§
DualACE/NEP inhibitors	Gemopatrilat Ilepatril Omapatrilat Sampatrilat
Neprilysin inhibitors	Sacubitril (+valsartan)
Other	Sparsentan
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

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