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Centalun

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Centalun
Clinical data
ATC code
  • none
Legal status
Legal status
  • In general: unscheduled
Identifiers
  • 2-methyl-1-phenylbut-3-yne-1,2-diol
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC11H12O2
Molar mass176.215 g·mol−1
3D model (JSmol)
  • OC(c1ccccc1)C(C#C)(O)C
  • InChI=1S/C11H12O2/c1-3-11(2,13)10(12)9-7-5-4-6-8-9/h1,4-8,10,12-13H,2H3 ☒N
  • Key:GQOXDWHRXDPZJK-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Centalun was developed by Boehringer Ingelheim in 1962[1] and is apsycholeptic drug withhypnotic andsedative effects, viaallosteric agonism of theGABAA receptor.[2] It was previously used for sedation in medical procedures such as surgery,[3] orthopedics[4] and gynecology,[5] although it is no longer in clinical use. Despite its history of clinical use, centalun was never incorporated into theCSA and therefore remains unregulated as a drug of abuse.

References

[edit]
  1. ^BE 618130, "Procédé pour l'obtention d'alkinediols" 
  2. ^Janke W, Glathe H (June 1964). "[Experimental Studies on the Psychic Effect of Sedatives Under Normal and Stress Conditions]".Psychologische Forschung (in German).27:377–402.doi:10.1007/bf00421338.PMID 14233519.S2CID 144088161.
  3. ^Monecke K (July 1964). "[Pre- and Postoperative Use of Centalun in Surgery]".Deutsches Medizinisches Journal (in German).15:470–1.PMID 14238754.
  4. ^Bruckschen E (July 1964). "[Sedative Therapy with Centalun in Orthopedics]".Deutsches Medizinisches Journal (in German).15:493–4.PMID 14243120.
  5. ^Gerlach W, Gerlach E (March 1964). "[Experiences with Centalun in Obstetrical and Gynecological Patients]".Medizinische Monatsschrift (in German).18:131–3.PMID 14193290.
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