Although there is a widely quoted cross-allergy risk of 10% between cephalosporins and penicillin, research has shown no increased risk for cross-allergy for cefprozil and several other second-generation or later cephalosporins.[6] The most common side effects were increased hepatic lab values (including AST and ALGT), dizziness, eosinophilia, diaper rash and superinfection, genital pruritus, vaginitis, diarrhea, nausea, vomiting, and abdominal pain.[5]
Spectrum of bacterial susceptibility and resistance
Cefprozil synthesis:[8][9][10] Separation of isomers:[11]
Displacement of the allylic chloride in intermediate (1) withtriphenylphosphine gives the phosphonium salt (2). This functionality is then converted to itsylide; condensation withacetaldehyde then leads to thevinyl derivative (3); deprotection then gives cefprozil. Semisynthetic oral cephalosporin consisting of ~90:10 Z/E isomeric mixture.[12][13]
^Albanus L, Björklund NE, Gustafsson B, Jönsson M (1975). "Forty days oral toxicity of 2,6-cis-diphenylhexamethylcyclotetrasiloxane (KABI 1774)in beagle dogs with special reference to effects on the male reproductive system".Acta Pharmacologica et Toxicologica.36 (Suppl 3):93–130.doi:10.1111/j.1600-0773.1975.tb03087.x.PMID1080338.
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