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| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a682860 |
| Pregnancy category |
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| Routes of administration | Intravenous |
| ATC code | |
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| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | n/a |
| Protein binding | 65 to 80% |
| Metabolism | Hepatic |
| Eliminationhalf-life | 30 minutes to 1 hour |
| Excretion | Renal |
| Identifiers | |
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| CAS Number |
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| PubChemCID | |
| DrugBank |
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| ChemSpider |
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| UNII | |
| KEGG |
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| ChEBI | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.005.288 |
| Chemical and physical data | |
| Formula | C16H16N2O6S2 |
| Molar mass | 396.43 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 160 to 160.5 °C (320.0 to 320.9 °F) |
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Cefalotin (INN)/ˌsɛfəˈloʊtɪn/ orcephalothin (USAN)/ˌsɛfəˈloʊθɪn/ is a first-generationcephalosporinantibiotic with broad spectrum antibiotic activity.[1][2] It was the first cephalosporin marketed (1964) and continues to be widely used.[3] Cefalotin is used for bacterial infections of the respiratory tract, urinary tract, skin, soft tissues, bones and joints, sepsis, peritonitis, osteomyelitis, mastitis, infected wounds, and post-operational infections.[2]
It is anintravenously administered agent with a similar antimicrobial spectrum tocefazolin and the oral agentscefalexin andcefadroxil.Cefalotin sodium is marketed asKeflin (Lilly) and under other trade names.[4]
The compound is a derivative ofthiophene-2-acetic acid.[5]
