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Cathepsin O

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
"CTSO" redirects here. For other uses, seeCareer and technical student organization.
CTSO
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1ATK,1AU0,1AU2,1AU3,1AU4,1AYU,1AYV,1AYW,1BGO,1BY8,1MEM,1NL6,1NLJ,1Q6K,1SNK,1TU6,1U9V,1U9W,1U9X,1VSN,1YK7,1YK8,1YT7,2ATO,2AUX,2AUZ,2BDL,2R6N,3C9E,3H7D,3KW9,3KWB,3KWZ,3KX1,3O0U,3O1G,3OVZ,4DMX,4DMY,7PCK,4LEG,4N79,4N8W

Identifiers
AliasesCTSO, CTSO1, cathepsin O
External IDsOMIM:600550;MGI:2139628;HomoloGene:1020;GeneCards:CTSO;OMA:CTSO - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for CTSO
Genomic location for CTSO
Band4q32.1Start155,921,580bp[1]
End155,953,912bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for CTSO
Genomic location for CTSO
Band3|3 E3Start81,839,908bp[2]
End81,864,032bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • gallbladder

  • endometrium

  • right coronary artery

  • smooth muscle tissue

  • placenta

  • gastric mucosa

  • liver

  • duodenum

  • monocyte
Top expressed in
  • gastrula

  • mesenteric lymph nodes

  • otolith organ

  • utricle

  • median eminence

  • carotid body

  • Epithelium of choroid plexus

  • left lobe of liver

  • decidua

  • white adipose tissue
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1519

229445

Ensembl

ENSG00000256043

ENSMUSG00000028015

UniProt

P43234

Q8BM88

RefSeq (mRNA)

NM_001334

NM_177662

RefSeq (protein)

NP_001325

NP_808330

Location (UCSC)Chr 4: 155.92 – 155.95 MbChr 3: 81.84 – 81.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cathepsin O is an enzyme encoded by theCTSOgene in humans.[5][6]

Function

[edit]

Cathepsin O is acysteine cathepsin, acysteine protease and a member of thecathepsin family. Thisproteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used assubstrates for cysteine proteinases, and its proteolytic activity was abolished by an inhibitor of cysteine proteinase.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000256043 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000028015 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Santamaría I, Pendás AM, Velasco G, López-Otín C (October 1998). "Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO)".Genomics.53 (2):231–4.doi:10.1006/geno.1997.5180.PMID 9790772.
  6. ^ab"Entrez Gene: cathepsin O".

Further reading

[edit]

External links

[edit]
  • TheMEROPS online database for peptidases and their inhibitors:C01.035

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Caspase
Fruit-derived
Calpain
Cathepsin
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