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Carboxypeptidase B (EC 3.4.17.2,protaminase,pancreatic carboxypeptidase B,tissue carboxypeptidase B,peptidyl-L-lysine [L-arginine]hydrolase) is acarboxypeptidase that preferentially cleaves off basicamino acids arginine andlysine from the C-terminus of a peptide.^[1]^[2]^[3]^[4] Thisenzyme is secreted by the pancreas, and it travels to the small intestine, where it aids in protein digestion. Plasma carboxypeptidase B (carboxypeptidase B2) is responsible for converting theC5a protein into C5a des-Arg, with one less amino acid.

References

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^Folk JE (1970). "Carboxypeptidase B (Porcine Pancreas)".Proteolytic Enzymes. Methods Enzymol. Vol. 19. pp. 504–508.doi:10.1016/0076-6879(70)19036-7.ISBN 9780121818814.
^Brodrick JW, Geokas MC, Largman C (December 1976). "Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion".Biochimica et Biophysica Acta (BBA) - Enzymology.452 (2):468–81.doi:10.1016/0005-2744(76)90197-2.PMID 1009123.
^Butterworth J, Duncan JJ (September 1979). "Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis".Clinica Chimica Acta; International Journal of Clinical Chemistry.97 (1):39–43.doi:10.1016/0009-8981(79)90023-8.PMID 40714.
^Wallace EF, Evans CJ, Jurik SM, Mefford IN, Barchas JD (1982). "Carboxypeptidase B activity from adrenal medulla--is it involved in the processing of proenkephalin?".Life Sciences.31 (16–17):1793–6.doi:10.1016/0024-3205(82)90212-0.PMID 6130442.

External links

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TheMEROPS online database for peptidases and their inhibitors:M14.003^{[dead link]}
Carboxypeptidase+B at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Hydrolase:proteases (EC 3.4)

3.4.11-19:Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O
3.4.13	Dipeptidase 1 2 3
3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II
3.4.15	Angiotensin-converting enzyme
3.4.16	Serine type carboxypeptidases:Cathepsin A DD-Transpeptidase
3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II
Other/ungrouped	Metalloexopeptidase

3.4.21-25:Endopeptidase

Other/ungrouped:Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

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