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Carboxypeptidase A2

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
CPA2
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1AYE,1DTD,1O6X

Identifiers
AliasesCPA2, carboxypeptidase A2
External IDsOMIM:600688;MGI:3617840;HomoloGene:37541;GeneCards:CPA2;OMA:CPA2 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for CPA2
Genomic location for CPA2
Band7q32.2Start130,266,863bp[1]
End130,289,798bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for CPA2
Genomic location for CPA2
Band6|6 A3.3Start30,541,581bp[2]
End30,564,475bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • islet of Langerhans

  • pancreatic epithelial cell

  • body of stomach

  • beta cell

  • duodenum

  • testicle

  • C1 segment

  • fundus

  • jejunal mucosa
Top expressed in
  • pyloric antrum

  • islet of Langerhans

  • embryo

  • duodenum

  • retinal pigment epithelium

  • genital tubercle

  • saccule

  • sexually immature organism

  • migratory enteric neural crest cell

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1358

232680

Ensembl

ENSG00000158516

ENSMUSG00000071553

UniProt

P48052

Q504N0

RefSeq (mRNA)

NM_001869

NM_001024698

RefSeq (protein)

NP_001860

NP_001019869

Location (UCSC)Chr 7: 130.27 – 130.29 MbChr 6: 30.54 – 30.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxypeptidase A2 is anenzyme that in humans is encoded by theCPA2gene.[5][6][7]

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues[7]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000158516 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000071553 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Catasus L, Vendrell J, Aviles FX, Carreira S, Puigserver A, Billeter M (Apr 1995)."The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model".J Biol Chem.270 (12):6651–7.doi:10.1074/jbc.270.12.6651.PMID 7896805.
  6. ^Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (Aug 2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32".Genomics.66 (2):221–5.doi:10.1006/geno.2000.6206.PMID 10860668.
  7. ^ab"Entrez Gene: CPA2 carboxypeptidase A2 (pancreatic)".

Further reading

[edit]

External links

[edit]
PDB gallery
  • 1aye: HUMAN PROCARBOXYPEPTIDASE A2
    1aye: HUMAN PROCARBOXYPEPTIDASE A2
  • 1dtd: CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE LEECH CARBOXYPEPTIDASE INHIBITOR AND THE HUMAN CARBOXYPEPTIDASE A2 (LCI-CPA2)
    1dtd: CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE LEECH CARBOXYPEPTIDASE INHIBITOR AND THE HUMAN CARBOXYPEPTIDASE A2 (LCI-CPA2)
  • 1o6x: NMR SOLUTION STRUCTURE OF THE ACTIVATION DOMAIN OF HUMAN PROCARBOXYPEPTIDASE A2
    1o6x: NMR SOLUTION STRUCTURE OF THE ACTIVATION DOMAIN OF HUMAN PROCARBOXYPEPTIDASE A2
3.4.11-19:Exopeptidase
3.4.11
3.4.13
3.4.14
3.4.15
3.4.16
3.4.17
Other/ungrouped
3.4.21-25:Endopeptidase
3.4.99: Unknown
Activity
Regulation
Classification
Kinetics
Types
Portal:


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