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Cannabidiorcol

From Wikipedia, the free encyclopedia
Phytocannabinoid
Pharmaceutical compound
Cannabidiorcol
Identifiers
  • 5-methyl-2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]benzene-1,3-diol
CAS Number
PubChemCID
ChemSpider
UNII
Chemical and physical data
FormulaC17H22O2
Molar mass258.361 g·mol−1
3D model (JSmol)
  • CC1=C[C@H]([C@@H](CC1)C(=C)C)C2=C(C=C(C=C2O)C)O
  • InChI=1S/C17H22O2/c1-10(2)13-6-5-11(3)7-14(13)17-15(18)8-12(4)9-16(17)19/h7-9,13-14,18-19H,1,5-6H2,2-4H3/t13-,14+/m0/s1
  • Key:GKVOVXWEBSQJPA-UONOGXRCSA-N

Cannabidiorcol (CBDO,CBD-C1,O-1821) is aphytocannabinoid found naturally inCannabis in trace concentrations. It is related tocannabidiol, with the pentyl side chain shortened to amethyl group. Cannabidiorcol has low affinity forcannabinoid receptors and is mainly active as an agonist of theTRPV2 cation channel, through which it producesantiinflammatory effects,[1] but can also promotetumorigenesis at high concentrations.[2]

See also

[edit]

References

[edit]
  1. ^Laragione T, Harris C, Gulko PS (March 2023)."Combination therapy of a TRPV2 agonist with a TNF inhibitor achieves sustained suppression of disease severity and reduced joint damage".Clinical and Experimental Immunology.211 (3):233–238.doi:10.1093/cei/uxac124.PMC 10038320.PMID 36571199.
  2. ^Huang R, Li S, Tian C, Zhou P, Zhao H, Xie W, et al. (November 2022)."Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma".British Journal of Cancer.127 (8):1424–1439.doi:10.1038/s41416-022-01896-2.PMC 9553907.PMID 35896815.
Phytocannabinoids
(comparison)
Cannabibutols
Cannabichromenes
Cannabicyclols
Cannabidiols
Cannabielsoins
Cannabigerols
Cannabiphorols
Cannabinols
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Cannabivarins
Delta-3-tetrahydrocannabinols
Delta-4-tetrahydrocannabinols
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  • Others:2-PG(directly potentiates activity of 2-AG at CB1 receptor)
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See also
Receptor/signaling modulators
Cannabinoids (cannabinoids by structure)
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