Part of the liver
Thecanals of Hering , orintrahepatic bile ductules , are part of the outflow system ofexocrine bile product from the liver.Liver stem cells are hypothesized to inhabit the canals.[ 1] [ 2]
They are found between thebile canaliculi andinterlobular bile ducts near the outer edge of aclassic liver lobule .[ 3] [ 4]
Histologically, the cells of the ductule are described assimple cuboidal epithelium , lined partially bycholangiocytes andhepatocytes . They may not be readily visible but can bedifferentially stained by cytokeratins CK19 and CK7.
The canals of Hering are destroyed early inprimary biliary cholangitis and may be primary sites of scarring inmethotrexate toxicity . Research has indicated the presence of intraorgan stem cells of the liver that can proliferate in disease states, so-called oval cells.[ 5] [ 6] [ 1]
They are named forEwald Hering .[ 7]
^a b Oliva, Joan; French, Barbara A.; Qing, X.; French, Samuel W. (2010)."The identification of stem cells in human liver diseases and hepatocellular carcinoma" .Experimental and Molecular Pathology .88 (3). Elsevier BV:331– 340.doi :10.1016/j.yexmp.2010.01.003 .ISSN 0014-4800 .PMC 3593713 ^ De Alwis, Nimantha; Hudson, Gavin; Burt, Alastair D.; Day, Christopher P.; Chinnery, Patrick F. (2009-07-07)."Human liver stem cells originate from the canals of hering" .Hepatology .50 (3). Ovid Technologies (Wolters Kluwer Health):992– 993.doi :10.1002/hep.23160 ISSN 0270-9139 . ^ Ross, M.H. & Pawlina, W. 2003.Histology: A Text and Atlas, 4th Edition. Lippincott Williams & Wilkins, Philadelphia. ^ Gartner, L.P. & Hiatt, J.L. 2000.Color Atlas of Histology, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia. ^ Saxena, R. & Theise, N. 2004.Canals of Hering: Recent Insights and Current Knowledge, Semin Liver Dis 24: 43-48. ^ Kordes, Claus; Häussinger, Dieter (2013-05-01)."Hepatic stem cell niches" .Journal of Clinical Investigation .123 (5). American Society for Clinical Investigation:1874– 1880.doi :10.1172/jci66027 .ISSN 0021-9738 .PMC 3638908 ^ Hering E. Uber den Bau der Wirbelthierleber. Archiv für mikroskopische Anatomie 1867;3:88–118 
