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Camizestrant

From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

Camizestrant
Clinical data

Other names	AZD9833
ATC code	None
Identifiers
IUPAC name N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]pyridin-3-amine
CAS Number	2222844-89-3
PubChemCID	134453496
IUPHAR/BPS	12716
DrugBank	DB19218
ChemSpider	103820855
UNII	JUP57A8EPZ
KEGG	D12049
ChEMBL	ChEMBL4650365
Chemical and physical data
Formula	C₂₄H₂₈F₄N₆
Molar mass	476.524 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@@H]1CC2=C(C=CC3=C2C=NN3)[C@H](N1CC(F)(F)F)C4=NC=C(C=C4)NC5CN(C5)CCCF
InChI InChI=1S/C24H28F4N6/c1-15-9-19-18(4-6-21-20(19)11-30-32-21)23(34(15)14-24(26,27)28)22-5-3-16(10-29-22)31-17-12-33(13-17)8-2-7-25/h3-6,10-11,15,17,23,31H,2,7-9,12-14H2,1H3,(H,30,32)/t15-,23+/m1/s1 Key:WDHOIABIERMLGY-CMJOXMDJSA-N

Camizestrant is aninvestigational new drug that is being evaluated to treatbreast cancer.^[1] It is anestrogen receptor alpha antagonist and aselective estrogen receptor degrader (SERD).^[2]

References

^"Camizestrant - AstraZeneca".AdisInsight. Springer Nature Switzerland AG.
^Scott JS, Moss TA, Balazs A, Barlaam B, Breed J, Carbajo RJ, et al. (December 2020). "Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist".Journal of Medicinal Chemistry.63 (23):14530–14559.doi:10.1021/acs.jmedchem.0c01163.PMID 32910656.

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