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| Formula | C6H6O7.C2H4N2.Ca |
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Calcium carbimide, sold as thecitratesalt under the trade nameTemposil, is adisulfiram-like medication. Its effects are similar to the medicationdisulfiram (Antabuse) in that it interferes with the normal metabolism ofalcohol by preventing the breakdown of the metabolic byproductacetaldehyde. The result is that when alcohol is consumed by users of calcium carbimide, they experience severe reactions which include symptoms such as sweating, difficulty breathing, rapid heartbeat, rash, nausea and vomiting, and headache.
A recent 9-year study found that incorporation of supervised carbimide and the similar medication, disulfiram, into a comprehensive treatment program resulted in an abstinence rate of over 50%.[1]
Temposil was developed by Drs. Ken Ferguson andGordon Bell, who tested the medication on themselves.[2][3][4] It was patented in 1955 by the Alcoholism Research Foundation of Ontario.[5]
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