Movatterモバイル変換

[0]ホーム

Jump to content

CYP39A1

Edit links

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

CYP39A1

Identifiers

Aliases

CYP39A1, cytochrome P450 family 39 subfamily A member 1

External IDs

OMIM:605994;MGI:1927096;HomoloGene:9580;GeneCards:CYP39A1;OMA:CYP39A1 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p12.3	Start	46,549,580bp^[1]
Band	6p12.3	End	46,652,830bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 B3	Start	43,978,316bp^[2]
Band	17\|17 B3	End	44,062,322bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

parotid gland

right lobe of liver

gastric mucosa

skin of abdomen

testicle

hair follicle

gonad

Epithelium of choroid plexus

corpus epididymis

skin of leg

Top expressed in

sciatic nerve

vestibular sensory epithelium

zygote

vestibular membrane of cochlear duct

lacrimal gland

ventricular zone

secondary oocyte

respiratory epithelium

olfactory epithelium

tail of embryo

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	iron ion binding metal ion binding monooxygenase activity steroid 7-alpha-hydroxylase activity heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity oxysterol 7-alpha-hydroxylase activity
Cellular component	organelle membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle membrane endoplasmic reticulum
Biological process	steroid metabolic process lipid metabolism digestion bile acid catabolic process cholesterol catabolic process lipid catabolic process sterol metabolic process bile acid biosynthetic process cholesterol homeostasis
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


51302


56050

Ensembl


ENSG00000146233


ENSMUSG00000023963

UniProt


Q9NYL5


Q9JKJ9

RefSeq (mRNA)


NM_001278738 NM_001278739 NM_016593


NM_001285947 NM_001285948 NM_018887

RefSeq (protein)


NP_001265667 NP_001265668 NP_057677


NP_001272876 NP_001272877 NP_061375

Location (UCSC)

Chr 6: 46.55 – 46.65 Mb

Chr 17: 43.98 – 44.06 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CYP39A1 (cytochromeP450, family39, subfamilyA, polypeptide1) also known asoxysterol 7-α-hydroxylase 2 is aprotein that in humans is encoded by theCYP39A1gene.^[5]

This gene encodes a member of thecytochrome P450 superfamily ofenzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. Thisendoplasmic reticulum protein is involved in the conversion ofcholesterol tobile acids. Its substrates include the oxysterols24-hydroxycholesterol,25-hydroxycholesterol and27-hydroxycholesterol.^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000146233 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000023963 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Li-Hawkins J, Lund EG, Bronson AD, Russell DW (June 2000)."Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol".J. Biol. Chem.275 (22):16543–9.doi:10.1074/jbc.M001810200.PMID 10748047.
^ This article incorporatespublic domain material from"Entrez Gene: CYP39A1".Reference Sequence collection.National Center for Biotechnology Information.

External links

[edit]

HumanCYP39A1 genome location andCYP39A1 gene details page in theUCSC Genome Browser.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants".Pharmacogenetics.14 (1):1–18.doi:10.1097/00008571-200401000-00001.PMID 15128046.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression".Nat. Biotechnol.19 (5):440–5.doi:10.1038/88107.PMID 11329013.S2CID 25064683.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Fourgeux C, Martine L, Björkhem I, et al. (2009)."Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels".Invest. Ophthalmol. Vis. Sci.50 (12):5712–7.doi:10.1167/iovs.09-3655.PMID 19553612.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

v t e Cytochromes,oxygenases:cytochrome P450 (Most belong toEC 1.14)
CYP1	A1 A2 A5 B1
CYP2	A6 A7 A13 B6 C8 C9 C18 C19 D6 E1 F1 J2 R1 S1 U1 W1
CYP3 (CYP3A)	A4 A5 A7 A37 A43
CYP4	A11 A22 B1 F2 F3 F8 F11 F12 F22 V2 X1 Z1
CYP5-20	CYP5 (A1) CYP6 (G1,M2) CYP7 (A1,B1) CYP8 (A1,B1) CYP9 CYP10 CYP11 (A1,A2,B1,B2,B3,C1) CYP12 CYP13 CYP14 CYP15 CYP16 CYP17 (A1) CYP18 CYP19 (A1) CYP20 (A1)
CYP21-49	CYP21 (A2) CYP22 (A1) CYP23 CYP24 (A1) CYP25 CYP26 (A1,B1,C1) CYP27 (A1,B1,C1) CYP28 (A1) CYP29 CYP35 (B1) CYP39 (A1) CYP46 (A1)
CYP51-69	CYP51 (A1,F1) CYP52 CYP53 A1 CYP55 A1 CYP56 A1 CYP61
CYP71-99	CYP71 (C1,C2,C3,C4,Z6,AJ4,AV1,BA1) CYP72A1 CYP73A1 CYP74 (D1) CYP75 (A1,B1) CYP76 (B6,M7) CYP79 (A1,A2,B1,B2,B3,D1,D2,D3,D4) CYP80 (A1,B1,G2) CYP81 (E1,E3,E7,E9) CYP88D6 CYP90C1 CYP93E1 CYP97C1 CYP99A3
CYP101-281	CYP101A1 CYP102A1 CYP105 A1 D7 CYP106A2 CYP107 A1 G1 CYP109 B1 E1 CYP111 CYP113A1 CYP119A1 CYP123 CYP125A1 CYP139 CYP147 CYP152 A1 B1 CYP154C3 CYP158A CYP161C CYP170 A1 B1 CYP176A1 CYP183A CYP197 CYP199A2 CYP255A
CYP301-499	CYP303A1 CYP305 M2 Halloween genes (CYP302A1,CYP306A1,CYP307A1,CYP307A2,CYP314A1,CYP315A1) CYP318A1
CYP501-699	CYP503 CYP504B1
CYP701-999	CYP704B22 CYP710 CYP720A1

This article on agene on humanchromosome 6 is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=CYP39A1&oldid=1204737407"

Categories:

Hidden categories:

[8]ページ先頭

Movatterモバイル変換

References

External links

Further reading