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CUL7

From Wikipedia, the free encyclopedia

Protein-coding gene in humans

CUL7

Available structures

Ortholog search:PDBe RCSB

List of PDB id codes
2JNG

Identifiers

CUL7, 3M1, KIAA0076, dJ20C7.5, cullin 7, CUL-7

External IDs

OMIM:609577;MGI:1913765;HomoloGene:56683;GeneCards:CUL7;OMA:CUL7 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p21.1	Start	43,037,617bp^[1]
Band	6p21.1	End	43,053,943bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 C	Start	46,961,263bp^[2]
Band	17\|17 C	End	46,975,290bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

stromal cell of endometrium

pituitary gland

anterior pituitary

right uterine tube

right adrenal gland

right adrenal cortex

right lobe of thyroid gland

ventricular zone

right hemisphere of cerebellum

canal of the cervix

Top expressed in

saccule

yolk sac

otic vesicle

otic placode

umbilical cord

internal carotid artery

external carotid artery

human fetus

efferent ductule

molar

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding ubiquitin protein ligase binding
Cellular component	cytoplasm cytosol centrosome Golgi apparatus microtubule organizing center Cul7-RING ubiquitin ligase complex perinuclear region of cytoplasm anaphase-promoting complex 3M complex cytoskeleton
Biological process	Golgi organization ubiquitin-dependent protein catabolic process placenta development mitotic cytokinesis proteolysis vasculogenesis IRE1-mediated unfolded protein response positive regulation of dendrite morphogenesis protein ubiquitination epithelial to mesenchymal transition viral process microtubule cytoskeleton organization regulation of mitotic nuclear division post-translational protein modification
Sources:Amigo /QuickGO

Species

Human

Mouse


9820


66515


ENSG00000044090


ENSMUSG00000038545


Q14999


Q8VE73

RefSeq (mRNA)


NM_001168370 NM_014780 NM_001374872 NM_001374873 NM_001374874


NM_025611

RefSeq (protein)


NP_001161842 NP_055595 NP_001361801 NP_001361802 NP_001361803


NP_079887

Location (UCSC)

Chr 6: 43.04 – 43.05 Mb

Chr 17: 46.96 – 46.98 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Cullin-7 is a RING-E3 ligaseprotein that in humans is encoded by theCUL7gene.^[5]^[6]^[7]

Clinical significance

It is associated with3-M syndrome.

Interactions

CUL7 has been shown tointeract withRBX1.^[5]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000044090 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000038545 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^bDias DC, Dolios G, Wang R, Pan ZQ (Dec 2002)."CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex".Proc Natl Acad Sci U S A.99 (26):16601–6.doi:10.1073/pnas.252646399.PMC 139190.PMID 12481031.
^Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA (Aug 2003)."Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis".Proc Natl Acad Sci U S A.100 (17):9855–60.Bibcode:2003PNAS..100.9855A.doi:10.1073/pnas.1733908100.PMC 187864.PMID 12904573.
^"Entrez Gene: CUL7 cullin 7".

Further reading

Kim SS, Shago M, Kaustov L, et al. (2007)."CUL7 is a novel antiapoptotic oncogene".Cancer Res.67 (20):9616–22.doi:10.1158/0008-5472.CAN-07-0644.PMID 17942889.
Jung P, Verdoodt B, Bailey A, et al. (2007)."Induction of cullin 7 by DNA damage attenuates p53 function".Proc. Natl. Acad. Sci. U.S.A.104 (27):11388–93.Bibcode:2007PNAS..10411388J.doi:10.1073/pnas.0609467104.PMC 2040908.PMID 17586686.
Skaar JR, Florens L, Tsutsumi T, et al. (2007)."PARC and CUL7 form atypical cullin RING ligase complexes".Cancer Res.67 (5):2006–14.doi:10.1158/0008-5472.CAN-06-3241.PMID 17332328.
Kaustov L, Lukin J, Lemak A, et al. (2007)."The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53".J. Biol. Chem.282 (15):11300–7.doi:10.1074/jbc.M611297200.PMID 17298945.
Kasper JS, Arai T, DeCaprio JA (2006). "A novel p53-binding domain in CUL7".Biochem. Biophys. Res. Commun.348 (1):132–8.doi:10.1016/j.bbrc.2006.07.013.PMID 16875676.
Andrews P, He YJ, Xiong Y (2006). "Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function".Oncogene.25 (33):4534–48.doi:10.1038/sj.onc.1209490.PMID 16547496.S2CID 36894787.
Huber C, Dias-Santagata D, Glaser A, et al. (2005). "Identification of mutations in CUL7 in 3-M syndrome".Nat. Genet.37 (10):1119–24.doi:10.1038/ng1628.PMID 16142236.S2CID 44003147.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Mungall AJ, Palmer SA, Sims SK, et al. (2003)."The DNA sequence and analysis of human chromosome 6".Nature.425 (6960):805–11.Bibcode:2003Natur.425..805M.doi:10.1038/nature02055.PMID 14574404.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003)."Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs".Genome Res.12 (11):1773–84.doi:10.1101/gr.406902.PMC 187542.PMID 12421765.
Winston JT, Koepp DM, Zhu C, et al. (1999)."A family of mammalian F-box proteins".Curr. Biol.9 (20):1180–2.Bibcode:1999CBio....9.1180W.doi:10.1016/S0960-9822(00)80021-4.PMID 10531037.S2CID 14341845.
Nomura N, Nagase T, Miyajima N, et al. (1995)."Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1".DNA Res.1 (5):223–9.doi:10.1093/dnares/1.5.223.PMID 7584044.

External links

GeneReviews/NIH/NCBI/UW entry on 3-M syndrome
OMIM entries entry on 3-M syndrome
HumanCUL7 genome location andCUL7 gene details page in theUCSC Genome Browser.
Overview of all the structural information available in thePDB forUniProt:Q14999 (Human Cullin-7) at thePDBe-KB.

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Cell cycle proteins

A (A1,A2)
B (B1,B2, B3)
D (D1,D2,D3)
E (E1,E2)

INK4a/ARF (p14arf/p16,p15,p18,p19)
cip/kip (p21,p27,p57)

P53 p63 p73 family

Other

Phases and
checkpoints

Interphase	G₁ phase S phase G₂ phase
M phase	Mitosis (Preprophase Prophase Prometaphase Metaphase Anaphase Telophase) Cytokinesis
Cell cycle checkpoints	Restriction point Spindle checkpoint Postreplication checkpoint
Other cellular phases	Apoptosis G₀ phase Meiosis

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