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CP 55,244

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
CP 55,244
Identifiers
  • (2S,4S,4aS,6R,8aR)-6-(Hydroxymethyl)-4-[2-hydroxy-4-(2-methyloctan-2-yl)phenyl]-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-ol
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC26H42O3
Molar mass402.619 g·mol−1
3D model (JSmol)
  • CCCCCCC(C)(C)c1ccc(c(c1)O)[C@H]2C[C@H](C[C@@H]3[C@@H]2C[C@@H](CC3)CO)O
  • InChI=1S/C26H42O3/c1-4-5-6-7-12-26(2,3)20-10-11-22(25(29)15-20)24-16-21(28)14-19-9-8-18(17-27)13-23(19)24/h10-11,15,18-19,21,23-24,27-29H,4-9,12-14,16-17H2,1-3H3/t18-,19-,21+,23+,24-/m1/s1
  • Key:ZAELPWSCABXXAB-QXASVXAKSA-N
  (verify)

CP 55,244 is achemical compound which is acannabinoid receptor agonist. It hasanalgesic effects and is used in scientific research. It is an extremely potentCB1 full agonist with aKi of 0.21 nM, making it more potent than the commonly used full agonistHU-210.[1][2]

See also

[edit]

References

[edit]
  1. ^Melvin LS, Milne GM, Johnson MR, Wilken GH, Howlett AC (November 1995). "Structure-activity relationships defining the ACD-tricyclic cannabinoids: cannabinoid receptor binding and analgesic activity".Drug Design and Discovery.13 (2):155–66.PMID 8872458.
  2. ^Griffin G, Wray EJ, Martin BR, Abood ME (October 1999)."Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum".British Journal of Pharmacology.128 (3):684–8.doi:10.1038/sj.bjp.0702806.PMC 1571656.PMID 10516649.
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