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CPCCOEt

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
CPCCOEt
Identifiers
  • (−)-ethyl (7E)-7-hydroxyimino-1,7a-dihydrocyclopropa[b]chromene-1a-carboxylate
CAS Number
PubChemCID
IUPHAR/BPS
ChEMBL
Chemical and physical data
FormulaC13H13NO4
Molar mass247.250 g·mol−1
3D model (JSmol)
  • CCOC(=O)C23Oc1ccccc1\C(=N\O)\C2C3
 ☒NcheckY (what is this?)  (verify)

CPCCOEt is a drug used in scientific research, which acts as a non-competitiveantagonist at themetabotropic glutamate receptor subtypemGluR1, with high selectivity although only moderatebinding affinity.[1][2] It is used mainly in basic research into the function of the mGluR1 receptor,[3][4] including the study of behavioural effects in animals including effects on memory and addiction.[5][6]

See also

[edit]

References

[edit]
  1. ^Litschig S, Gasparini F, Rueegg D, Stoehr N, Flor PJ, Vranesic I, Prézeau L, Pin JP, Thomsen C, Kuhn R (March 1999). "CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding".Molecular Pharmacology.55 (3):453–61.PMID 10051528.
  2. ^Ott D, Floersheim P, Inderbitzin W, Stoehr N, Francotte E, Lecis G, Richert P, Rihs G, Flor PJ, Kuhn R, Gasparini F (November 2000). "Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester".Journal of Medicinal Chemistry.43 (23):4428–36.doi:10.1021/jm0009944.PMID 11087567.
  3. ^Fukunaga I, Yeo CH, Batchelor AM (February 2007). "The mGlu1 antagonist CPCCOEt enhances the climbing fibre response in Purkinje neurones independently of glutamate receptors".Neuropharmacology.52 (2):450–8.doi:10.1016/j.neuropharm.2006.08.014.PMID 17045308.S2CID 40361285.
  4. ^Sugiyama Y, Kawaguchi SY, Hirano T (February 2008). "mGluR1-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron".The European Journal of Neuroscience.27 (4):884–96.doi:10.1111/j.1460-9568.2008.06063.x.PMID 18279362.S2CID 25581416.
  5. ^Lominac KD, Kapasova Z, Hannun RA, Patterson C, Middaugh LD, Szumlinski KK (November 2006). "Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties".Drug and Alcohol Dependence.85 (2):142–56.doi:10.1016/j.drugalcdep.2006.04.003.PMID 16697125.
  6. ^Kim J, Lee S, Park H, Song B, Hong I, Geum D, Shin K, Choi S (March 2007). "Blockade of amygdala metabotropic glutamate receptor subtype 1 impairs fear extinction".Biochemical and Biophysical Research Communications.355 (1):188–93.doi:10.1016/j.bbrc.2007.01.125.PMID 17292864.
Group I
mGluR1Tooltip Metabotropic glutamate receptor 1
mGluR5Tooltip Metabotropic glutamate receptor 5
Group II
mGluR2Tooltip Metabotropic glutamate receptor 2
mGluR3Tooltip Metabotropic glutamate receptor 3
Group III
mGluR4Tooltip Metabotropic glutamate receptor 4
mGluR6Tooltip Metabotropic glutamate receptor 6
mGluR7Tooltip Metabotropic glutamate receptor 7
mGluR8Tooltip Metabotropic glutamate receptor 8


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