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COUP-TFI

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From Wikipedia, the free encyclopedia

Protein found in humans

NR2F1

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2EBL

Identifiers

Aliases

NR2F1, BBOAS, BBSOAS, COUP-TFI, EAR-3, EAR3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1, nuclear receptor subfamily 2 group F member 1, COUPTF1

External IDs

OMIM:132890;MGI:1352451;HomoloGene:21158;GeneCards:NR2F1;OMA:NR2F1 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q15	Start	93,583,222bp^[1]
Band	5q15	End	93,594,611bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13 C1\|13 41.38 cM	Start	78,337,092bp^[2]
Band	13 C1\|13 41.38 cM	End	78,347,876bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ventricular zone

optic nerve

seminal vesicula

trigeminal ganglion

left uterine tube

germinal epithelium

ganglionic eminence

parietal pleura

lower lobe of lung

primary visual cortex

Top expressed in

vestibular membrane of cochlear duct

lateral geniculate nucleus

anterior amygdaloid area

barrel cortex

medial dorsal nucleus

ventricular zone

vas deferens

saccule

ciliary body

subiculum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA-binding transcription factor activity steroid hormone receptor activity sequence-specific DNA binding transcription coactivator activity DNA binding nuclear receptor activity zinc ion binding protein binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific retinoic acid-responsive element binding
Cellular component	nucleus nucleoplasm cytosol
Biological process	transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated signal transduction steroid hormone mediated signaling pathway intracellular receptor signaling pathway positive regulation of nucleic acid-templated transcription nervous system development negative regulation of neuron projection development positive regulation of transcription by RNA polymerase II
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


7025


13865

Ensembl


ENSG00000175745


ENSMUSG00000069171

UniProt


P10589


Q60632

RefSeq (mRNA)


NM_005654


NM_010151 NM_001347538 NM_001347539

RefSeq (protein)


NP_005645

NP_001334467 NP_001334468 NP_034281 NP_001390702 NP_001390704
NP_001390706

Location (UCSC)

Chr 5: 93.58 – 93.59 Mb

Chr 13: 78.34 – 78.35 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

COUP-TF1 (COUPTranscriptionFactor1) also known asNR2F1 (NuclearReceptor subfamily2, groupF, member1) is aprotein that in humans is encoded by theNR2F1gene.^[5]^[6] This protein is a member ofnuclear hormone receptor family ofsteroid hormone receptors.

Function

[edit]

Coup (chickenovalbumin upstream promoter)transcription factor binds to the ovalbuminpromoter and, in conjunction with another protein (S300-II) stimulatesinitiation of transcription.^[7]^[8] COUP-TF1 binds to both direct repeats andpalindromes of the 5'-AGGTCA-3' motif.^[9]

Interactions

[edit]

COUP-TFI has been shown tointeract with:

Clinical

[edit]

Mutations in this gene have been associated withBosch-Boonstra-Schaaf optic atrophy syndrome.^[13]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000175745 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000069171 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1".
^Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (Sep 1995)."Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes".Genomics.29 (1):240–6.doi:10.1006/geno.1995.1237.PMID 8530078.
^Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW (Dec 1986)."Identification of two factors required for transcription of the ovalbumin gene".Molecular and Cellular Biology.6 (12):4259–67.doi:10.1128/MCB.6.12.4259.PMC 367207.PMID 3796602.
^Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW (Aug 1987). "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)".Cell.50 (5):701–9.doi:10.1016/0092-8674(87)90328-X.PMID 3040258.S2CID 25136877.
^Tsai SY,Tsai MJ (Apr 1997)."Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age".Endocrine Reviews.18 (2):229–40.doi:10.1210/edrv.18.2.0294.PMID 9101138.
^^a ^bAvram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (Apr 2000)."Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors".The Journal of Biological Chemistry.275 (14):10315–22.doi:10.1074/jbc.275.14.10315.PMC 2819356.PMID 10744719.
^Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (May 1999)."Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily".Molecular and Cellular Biology.19 (5):3383–94.doi:10.1128/mcb.19.5.3383.PMC 84131.PMID 10207062.
^Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002)."Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK".The EMBO Journal.21 (13):3443–53.doi:10.1093/emboj/cdf344.PMC 126093.PMID 12093745.
^Hobbs MM, Wolters WC, Rayapati AO (2020) Bosch-Boonstra-Schaaf optic atrophy syndrome presenting as new-onset psychosis in a 32-year-old man: A case report and literature review. J Psychiatr Pract 26(1):58-62

External links

[edit]

HumanNR2F1 genome location andNR2F1 gene details page in theUCSC Genome Browser.
HumanNR2F2 genome location andNR2F2 gene details page in theUCSC Genome Browser.

Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM (Feb 1992)."Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling".Proceedings of the National Academy of Sciences of the United States of America.89 (4):1448–52.Bibcode:1992PNAS...89.1448K.doi:10.1073/pnas.89.4.1448.PMC 48468.PMID 1311101.
Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA (Sep 1992)."Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein".Molecular Endocrinology.6 (9):1468–78.doi:10.1210/mend.6.9.1331778.PMID 1331778.S2CID 24291055.
Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW (Sep 1992)."Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II)".The Journal of Biological Chemistry.267 (25):17617–23.doi:10.1016/S0021-9258(19)37087-5.PMID 1517211.
Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW (Jul 1989). "COUP transcription factor is a member of the steroid receptor superfamily".Nature.340 (6229):163–6.Bibcode:1989Natur.340..163W.doi:10.1038/340163a0.PMID 2739739.S2CID 4364164.
Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T (Dec 1988)."Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other".Nucleic Acids Research.16 (23):11057–74.doi:10.1093/nar/16.23.11057.PMC 338996.PMID 2905047.
Sawaya BE, Rohr O, Aunis D, Schaeffer E (Sep 1996)."Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells".The Journal of Biological Chemistry.271 (38):23572–6.doi:10.1074/jbc.271.38.23572.PMID 8798567.
Rohr O, Aunis D, Schaeffer E (Dec 1997)."COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells".The Journal of Biological Chemistry.272 (49):31149–55.doi:10.1074/jbc.272.49.31149.PMID 9388268.
Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (May 1999)."Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily".Molecular and Cellular Biology.19 (5):3383–94.doi:10.1128/mcb.19.5.3383.PMC 84131.PMID 10207062.
Klinge CM, Kaur K, Swanson HI (Jan 2000). "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1".Archives of Biochemistry and Biophysics.373 (1):163–74.doi:10.1006/abbi.1999.1552.PMID 10620335.
Rohr O, Schwartz C, Hery C, Aunis D, Tardieu M, Schaeffer E (Jan 2000)."The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells".The Journal of Biological Chemistry.275 (4):2654–60.doi:10.1074/jbc.275.4.2654.PMID 10644726.
Sugiyama T, Wang JC, Scott DK, Granner DK (Feb 2000)."Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene".The Journal of Biological Chemistry.275 (5):3446–54.doi:10.1074/jbc.275.5.3446.PMID 10652338.
Vlahou A, Flytzanis CN (Feb 2000)."Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle".Developmental Biology.218 (2):284–98.doi:10.1006/dbio.1999.9456.PMID 10656770.
Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (Apr 2000)."Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors".The Journal of Biological Chemistry.275 (14):10315–22.doi:10.1074/jbc.275.14.10315.PMC 2819356.PMID 10744719.
Gay F, Anglade I, Gong Z, Salbert G (Oct 2000)."The LIM/homeodomain protein islet-1 modulates estrogen receptor functions".Molecular Endocrinology.14 (10):1627–48.doi:10.1210/me.14.10.1627.PMID 11043578.
You M, Fischer M, Cho WK, Crabb D (Feb 2002)."Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors".Archives of Biochemistry and Biophysics.398 (1):79–86.doi:10.1006/abbi.2001.2713.PMID 11811951.
Lin F, Kolluri SK, Chen GQ, Zhang XK (Jun 2002)."Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor".The Journal of Biological Chemistry.277 (24):21414–22.doi:10.1074/jbc.M201885200.PMID 11934895.
Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002)."Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK".The EMBO Journal.21 (13):3443–53.doi:10.1093/emboj/cdf344.PMC 126093.PMID 12093745.
Yu X, Mertz JE (Feb 2003)."Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1".Journal of Virology.77 (4):2489–99.doi:10.1128/JVI.77.4.2489-2499.2003.PMC 141100.PMID 12551987.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Transcription factors andintracellular receptors

(1) Basic domains

(1.1) Basicleucine zipper (bZIP)

Activating transcription factor
- AATF
- 1
- 2
- 3
- 4
- 5
- 6
- 7
AP-1
- c-Fos
- FOSB
- FOSL1
- FOSL2
- JDP2
- c-Jun
- JUNB
- JunD
BACH
- 1
- 2
BATF
BLZF1
C/EBP
- α
- β
- γ
- δ
- ε
- ζ
CREB
- 1
- 3
- L1
CREM
DBP
DDIT3
GABPA
GCN4
HLF
MAF
- B
- sMaf
  - F
  - G
  - K
NFE
- 2
- L1
- L2
- L3
NFIL3
NRL
NRF
- 1
- 2
- 3
XBP1

(1.2) Basic helix-loop-helix (bHLH)

Group A	AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 NeuroD 1 2 Neurogenins 1 2 3 OLIG 1 2 Paraxis TCF15 Scleraxis SLC LYL1 TAL 1 2 Twist
Group B	FIGLA Myc c-Myc l-Myc n-Myc MXD4 TCF4
Group C bHLH-PAS	AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2
Group D	DEC 1 2 BHLHA9 Pho4 ID 1 2 3 4
Group E	HES 1 2 3 4 5 6 7 HEY 1 2 L
Group F bHLH-COE	EBF1

(1.3)bHLH-ZIP

(1.4) NF-1

NFI
- A
- B
- C
- X
SMAD
- R-SMAD
  - 1
  - 2
  - 3
  - 5
  - 9
- I-SMAD
  - 6
  - 7
- 4)

(1.5) RF-X

RFX
- 1
- 2
- 3
- 4
- 5
- 6
- ANK

(1.6) Basic helix-span-helix (bHSH)

AP-2
- α
- β
- γ
- δ
- ε

(2)Zinc finger DNA-binding domains

(2.1)Nuclear receptor(Cys₄)

subfamily 1	Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR
subfamily 2	COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX
subfamily 3	Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ
subfamily 4	NUR NGFIB NOR1 NURR1
subfamily 5	LRH-1 SF1
subfamily 6	GCNF
subfamily 0	DAX1 SHP

(2.2) Other Cys₄

GATA
- 1
- 2
- 3
- 4
- 5
- 6
MTA
- 1
- 2
- 3
TRPS1

(2.3) Cys₂His₂

General transcription factors
- TFIIA
- TFIIB
- TFIID
- TFIIE
  - 1
  - 2
- TFIIF
- 1
- 2
  - TFIIH
  - 1
  - 2
  - 4
  - 2I
  - 3A
  - 3C1
  - 3C2

ATBF1
BCL
- 6
- 11A
- 11B
CTCF
E4F1
EGR
- 1
- 2
- 3
- 4
ERV3
GFI1
GLI family
- 1
- 2
- 3
- REST
- S1
- S2
- YY1
HIC
- 1
- 2
HIVEP
- 1
- 2
- 3
IKZF
- 1
- 2
- 3
ILF
- 2
- 3
Sp/KLF family
- KLF
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - 7
  - 8
  - 9
  - 10
  - 11
  - 12
  - 13
  - 14
  - 15
  - 17
- SP
  - 1
  - 2
  - 4
  - 7
  - 8
MTF1
MYT1
OSR1
PRDM9
SALL
- 1
- 2
- 3
- 4
TSHZ3
WT1
Zbtb7
- 7A
- 7B
ZBTB
- 11
- 16
- 17
- 20
- 21
- 32
- 33
- 40
zinc finger
- 3
- 7
- 9
- 10
- 19
- 22
- 24
- 33B
- 34
- 35
- 41
- 43
- 44
- 51
- 74
- 143
- 146
- 148
- 165
- 202
- 217
- 219
- 238
- 239
- 259
- 267
- 268
- 281
- 300
- 318
- 330
- 346
- 350
- 365
- 366
- 384
- 423
- 451
- 452
- 471
- 593
- 638
- 644
- 649
- 655
- 804A

(2.4) Cys₆

HIVEP1

(2.5) Alternating composition

AIRE
DIDO1
GRLF1
ING
- 1
- 2
- 4
JARID
- 1A
- 1B
- 1C
- 1D
- 2
JMJD1B

(2.6) WRKY

WRKY

(3)Helix-turn-helixdomains

(3.1)Homeodomain

Antennapedia
ANTP class

protoHOX Hox-like	ParaHox Gsx 1 2 Xlox PDX1 Cdx 1 2 4 extended Hox:Evx1 Evx2 MEOX1 MEOX2 Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 GBX1 GBX2 MNX1
metaHOX NK-like	BARHL1 BARHL2 BARX1 BARX2 BSX DBX 1 2 DLX 1 2 3 4 5 6 EMX 1 2 EN 1 2 HHEX HLX LBX1 LBX2 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 HMX1 HMX2 HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2

other

ARX
CRX
CUTL1
FHL
- 1
- 2
- 3
HESX1
HOPX
LMX
- 1A
- 1B
NOBOX
TALE
- IRX
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - MKX
- MEIS
  - 1
  - 2
- PBX
  - 1
  - 2
  - 3
- PKNOX
  - 1
  - 2
- SIX
  - 1
  - 2
  - 3
  - 4
  - 5
PHF
- 1
- 3
- 6
- 8
- 10
- 16
- 17
- 20
- 21A
POU domain
- PIT-1
- BRN-3:A
- B
- C
- Octamer transcription factor:1
- 2
- 3/4
- 6
- 7
- 11
SATB2
ZEB
- 1
- 2

(3.2) Paired box

PAX
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
PRRX
- 1
- 2
PROP1
PHOX
- 2A
- 2B
RAX
SHOX
SHOX2
VSX1
VSX2
Bicoid
- GSC
- BICD2
- OTX
  - 1
  - 2
- PITX
  - 1
  - 2
  - 3

(3.3)Fork head /winged helix

E2F
- 1
- 2
- 3
- 4
- 5
FOX proteins
- A1
- A2
- A3
- B1
- B2
- C1
- C2
- D1
- D2
- D3
- D4
- D4L1
- D4L3
- D4L4
- D4L5
- D4L6
- E1
- E3
- F1
- F2
- G1
- H1
- I1
- I2
- I3
- J1
- J2
- J3
- K1
- K2
- L1
- L2
- M1
- N1
- N2
- N3
- N4
- O1
- O3
- O4
- O6
- P1
- P2
- P3
- P4
- Q1
- R1
- R2
- S1

(3.4)Heat shock factors

HSF
- 1
- 2
- 4

(3.5) Tryptophan clusters

ELF
- 2
- 4
- 5
EHF
ELK
- 1
- 3
- 4
ERF
ETS
- 1
- 2
- ERG
- SPIB
ETV
- 1
- 4
- 5
- 6
FLI1
Interferon regulatory factors
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
MYB
MYBL2

(3.6) TEA domain

transcriptional enhancer factor
- 1
- 2
- 3
- 4

(4)β-Scaffold factors with minor groove contacts

(4.1)Rel homology region	NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5
(4.2)STAT	STAT 1 2 3 4 5 6
(4.3) p53-like	p53 p63 p73 family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF
(4.4)MADS box	Mef2 A B C D SRF
(4.6)TATA-binding proteins	TBP TBPL1
(4.7)High-mobility group	BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 17 18 21 SRY SSRP1 TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4
(4.9) Grainyhead	TFCP2
(4.10) Cold-shock domain	CSDA YBX1
(4.11) Runt	CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA 1 2 HBP1
(0.3)Pocket domain	Rb RBL1 RBL2
(0.5)AP-2/EREBP-related factors	Apetala 2 EREBP B3
(0.6) Miscellaneous	ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma

see alsotranscription factor/coregulator deficiencies

Retrieved from "https://en.wikipedia.org/w/index.php?title=COUP-TFI&oldid=1300833583"

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[8]ページ先頭

Movatterモバイル変換

Function

Interactions

Clinical

References

External links

Further reading