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CHMP4B

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

CHMP4B

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
3C3Q,3UM3,4ABM

Identifiers

Aliases

CHMP4B, C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4, charged multivesicular body protein 4B

External IDs

OMIM:610897;MGI:1922858;HomoloGene:57102;GeneCards:CHMP4B;OMA:CHMP4B - orthologs

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	20q11.22	Start	33,811,348bp^[1]
Band	20q11.22	End	33,854,366bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 H1	Start	154,493,625bp^[2]
Band	2\|2 H1	End	154,536,705bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of ileum

skin of arm

tibialis anterior muscle

nasal epithelium

mucosa of transverse colon

cartilage tissue

cardiac muscle tissue of right atrium

muscle layer of sigmoid colon

gastric mucosa

tibial arteries

Top expressed in

vestibular membrane of cochlear duct

Ileal epithelium

Epithelium of choroid plexus

transitional epithelium of urinary bladder

conjunctival fornix

substantia nigra

facial motor nucleus

anterior horn of spinal cord

iris

motor neuron

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein homodimerization activity protein binding identical protein binding cadherin binding
Cellular component	cytoplasm ESCRT III complex cytosol endosome membrane late endosome membrane cytoplasmic side of plasma membrane membrane coat extracellular exosome vesicle midbody nuclear envelope nucleus
Biological process	negative regulation of autophagosome assembly regulation of centrosome duplication viral life cycle nucleus organization maintenance of lens transparency multivesicular body assembly negative regulation of cell death regulation of mitotic spindle assembly autophagy endosomal transport posttranslational protein targeting to endoplasmic reticulum membrane ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway protein transport septum digestion after cytokinesis mitotic metaphase plate congression protein homooligomerization vacuolar transport negative regulation of neuron death nuclear membrane reassembly exit from mitosis mitotic cytokinesis regulation of autophagy membrane fission macroautophagy transport viral budding via host ESCRT complex midbody abscission
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


128866


75608

Ensembl


ENSG00000101421


ENSMUSG00000038467

UniProt


Q9H444


Q9D8B3

RefSeq (mRNA)


NM_176812


NM_029362

RefSeq (protein)


NP_789782


NP_083638

Location (UCSC)

Chr 20: 33.81 – 33.85 Mb

Chr 2: 154.49 – 154.54 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Charged multivesicular body protein 4b is aprotein that in humans is encoded by theCHMP4Bgene.^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000101421 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000038467 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Katoh K, Shibata H, Hatta K, Maki M (Dec 2003). "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms".Arch Biochem Biophys.421 (1):159–65.doi:10.1016/j.abb.2003.09.038.PMID 14678797.
^"Entrez Gene: CHMP4B chromatin modifying protein 4B".