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CHD5

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

CHD5
Identifiers
AliasesCHD5, CHD-5, chromodomain helicase DNA binding protein 5, PMNDS
External IDsOMIM:610771;MGI:3036258;HomoloGene:56712;GeneCards:CHD5;OMA:CHD5 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CHD5
Genomic location for CHD5
Band1p36.31Start6,101,787bp[1]
End6,180,321bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for CHD5
Genomic location for CHD5
Band4|4 E2Start152,423,108bp[2]
End152,474,651bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • right frontal lobe

  • cingulate gyrus

  • anterior cingulate cortex

  • Brodmann area 10

  • Brodmann area 9

  • Pituitary Gland

  • left testis

  • right testis

  • primary visual cortex
Top expressed in
  • subiculum

  • central gray substance of midbrain

  • dorsal tegmental nucleus

  • cingulate gyrus

  • visual cortex

  • habenula

  • lateral hypothalamus

  • primary visual cortex

  • medial vestibular nucleus

  • paraventricular nucleus of hypothalamus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26038

269610

Ensembl

ENSG00000116254

ENSMUSG00000005045

UniProt

Q8TDI0

A2A8L1

RefSeq (mRNA)

NM_015557

NM_001081376
NM_029216
NM_001369243

RefSeq (protein)

NP_056372

NP_001074845
NP_083492
NP_001356172

Location (UCSC)Chr 1: 6.1 – 6.18 MbChr 4: 152.42 – 152.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chromodomain-helicase-DNA-binding protein 5 is anenzyme that inhumans is encoded by theCHD5gene.[5][6][7] It is a part of theCHD subfamily of ATP-dependent chromatin remodeling complexes.

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000116254 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000005045 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Schuster EF, Stoger R (Mar 2002). "CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases".Mamm Genome.13 (2):117–9.doi:10.1007/s00335-001-3042-6.PMID 11889561.S2CID 1694959.
  6. ^Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM (Feb 2003)."CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system".Oncogene.22 (7):1002–11.doi:10.1038/sj.onc.1206211.PMID 12592387.
  7. ^"Entrez Gene: CHD5 chromodomain helicase DNA binding protein 5".

External links

[edit]

Further reading

[edit]
PDB gallery
  • 1mm2: Solution structure of the 2nd PHD domain from Mi2b
    1mm2: Solution structure of the 2nd PHD domain from Mi2b


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