Movatterモバイル変換

[0]ホーム

Jump to content

CGP-35348

Edit links

From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

CGP-35348
Identifiers

IUPAC name 3-Aminopropyl(diethoxymethyl)phosphinic acid
CAS Number	123690-79-9^Y
PubChemCID	107699
IUPHAR/BPS	1069
ChemSpider	96869^N
UNII	87TI61875H
CompTox Dashboard(EPA)	DTXSID70154064
Chemical and physical data
Formula	C₈H₂₀NO₄P
Molar mass	225.225 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCOC(OCC)P(=O)(CCCN)O
InChI InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)^N Key:QIIVUOWTHWIXFO-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

CGP-35348 is a compound used in scientific research which acts as anantagonist atGABA_B receptors.^[1]^[2]^[3]

CGP-35348 was ineffective up to 100 μM to antagonize the inhibitory release of GABA elicited by baclofen, doing so selectively as aGABA_B heteroreceptor antagonist.^[4] Moreover, CGP-35348 was about threefold less potent in antagonizinggamma-hydroxybutyrate (GHB) andgamma-butyrolactone (GBL) thanbaclofen andSKF-97,541.^[5]

References

[edit]

^Carter LP, Chen W, Coop A, Koek W, France CP (May 2006). "Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348".European Journal of Pharmacology.538 (1–3):85–93.doi:10.1016/j.ejphar.2006.03.039.PMID 16647701.
^Nasrallah FA, Griffin JL, Balcar VJ, Rae C (August 2007). "Understanding your inhibitions: modulation of brain cortical metabolism by GABA(B) receptors".Journal of Cerebral Blood Flow and Metabolism.27 (8):1510–20.doi:10.1038/sj.jcbfm.9600453.PMID 17293844.S2CID 16069846.
^Koek W, Mercer SL, Coop A, France CP (September 2009)."Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348)".The Journal of Pharmacology and Experimental Therapeutics.330 (3):876–83.doi:10.1124/jpet.109.151845.PMC 2729800.PMID 19564487.
^Maurizio Raiteri (2006). "Functional Pharmacology in Human Brain".Pharmacological Reviews.58 (2):162–193.doi:10.1124/pr.58.2.5.PMID 16714485.S2CID 14404544.
^Koek W1, Mercer SL, Coop A. (June 2007). "Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348".Psychopharmacology.192 (3):407–14.doi:10.1007/s00213-007-0718-y.PMID 17277933.S2CID 25049526.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)