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CFU-Meg

From Wikipedia, the free encyclopedia
Colony forming unit for megakaryocytes in the bone marrow
CFU-Meg
Details
Gives rise toMegakaryocytes and those toplatelets
LocationBone marrow
FunctionColony forming unit
Identifiers
THH2.00.04.3.02013
Anatomical terms of microanatomy

CFU-Meg is acolony forming unit.Haematopoiesis in thebone marrow starts off from ahaematopoietic stem cell (HSC) and this can differentiate into themyeloid andlymphoid cell lineages. In order to eventually produce amegakaryocyte, the haematopoietic stem cell must generate myeloid cells, so it becomes a common myeloidprogenitor,CFU-GEMM. This in turn develops into CFU-Meg, which is the colony forming unit that leads to the production of megakaryocytes.[1][2][3]

Some sources prefer the term "CFU-Mega".[4]

See also

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References

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  1. ^Kimura H, Ohkoshi T, Matsuda S, Uchida T, Kariyone S (1988). "Megakaryocytopoiesis in polycythemia vera: characterization by megakaryocytic progenitors (CFU-Meg) in vitro and quantitation of marrow megakaryocytes".Acta Haematol.79 (1):1–6.doi:10.1159/000205681.PMID 3124455.
  2. ^Kimura H, Ishibashi T, Sato T, Matsuda S, Uchida T, Kariyone S (January 1987). "Megakaryocytic colony formation (CFU-Meg) in essential thrombocythemia: quantitative and qualitative abnormalities of bone marrow CFU-Meg".Am. J. Hematol.24 (1):23–30.doi:10.1002/ajh.2830240104.PMID 3799592.S2CID 20893511.
  3. ^Gallicchio VS, Hughes NK, Hulette BC, Noblitt L (December 1991)."Effect of interleukin-1, GM-CSF, erythropoietin, and lithium on the toxicity associated with 3'-azido-3'-deoxythymidine (AZT) in vitro on hematopoietic progenitors (CFU-GM, CFU-MEG, and BFU-E) using murine retrovirus-infected hematopoietic cells".J. Leukoc. Biol.50 (6):580–6.doi:10.1002/jlb.50.6.580.PMID 1940611.S2CID 9700067.[permanent dead link]
  4. ^Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005).Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 621.ISBN 0-7216-0187-1.

External links

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Myeloid blood cells andplasma
Hematopoiesis
Myelopoiesis
(CFU-GEMM)
CFU-GM
MEP
General
Myeloid tissue
Granulocytes
Monocytes
Macrophages
Other
Platelets
Red blood cells
Immune response
Other
Other
Myeloid blood cells andplasma
Hematopoiesis
Myelopoiesis
(CFU-GEMM)
CFU-GM
MEP
General
Myeloid tissue
Granulocytes
Monocytes
Macrophages
Other
Platelets
Red blood cells
Immune response
Other
Other


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