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CENPK

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

CENPK

Identifiers

Aliases

CENPK, AF5alpha, CENP-K, P33, Solt, FKSG14, centromere protein K

External IDs

OMIM:611502;MGI:1926210;HomoloGene:11035;GeneCards:CENPK;OMA:CENPK - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q12.3	Start	65,517,766bp^[1]
Band	5q12.3	End	65,563,168bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13\|13 D1	Start	104,365,119bp^[2]
Band	13\|13 D1	End	104,388,900bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

ventricular zone

testicle

secondary oocyte

gonad

ganglionic eminence

thymus

rectum

appendix

bone marrow

Top expressed in

fetal liver hematopoietic progenitor cell

medial ganglionic eminence

primitive streak

genital tubercle

vas deferens

spermatid

otic placode

Paneth cell

embryo

maxillary prominence

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding
Cellular component	cytosol nucleus nucleoplasm chromosome, centromeric region chromosome kinetochore
Biological process	CENP-A containing chromatin assembly kinetochore assembly mitotic sister chromatid segregation
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


64105


60411

Ensembl


ENSG00000123219


ENSMUSG00000021714

UniProt


Q9BS16


Q9ESN5

RefSeq (mRNA)


NM_001267038 NM_022145 NM_001349367 NM_001349368 NM_001349369


NM_021790 NM_181061 NM_001377093 NM_001377094 NM_001377095

RefSeq (protein)


NP_001253967 NP_071428 NP_001336296 NP_001336297 NP_001336298


NP_068562 NP_851406 NP_001364022 NP_001364023 NP_001364024

Location (UCSC)

Chr 5: 65.52 – 65.56 Mb

Chr 13: 104.37 – 104.39 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Centromere protein K is aprotein that in humans is encoded by theCENPKgene.^[5]^[6]

Interactions

[edit]

CENPK has been shown tointeract withSOX6.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000123219 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000021714 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Taki T, Hayashi Y, Taniwaki M, Seto M, Ueda R, Hanada R, Suzukawa K, Yokota J, Morishita K (Nov 1996). "Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia".Oncogene.13 (10):2121–30.PMID 8950979.
^"Entrez Gene: CENPK centromere protein K".
^Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000)."Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis".FEBS Letters.481 (2):147–51.doi:10.1016/S0014-5793(00)01987-6.PMID 10996314.S2CID 20831354.