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CENPI

From Wikipedia, the free encyclopedia
Protein-coding gene in humans
CENPI
Identifiers
AliasesCENPI, CENP-I, FSHPRH1, LRPR1, Mis6, centromere protein I
External IDsOMIM:300065;MGI:2147897;HomoloGene:4899;GeneCards:CENPI;OMA:CENPI - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for CENPI
Genomic location for CENPI
BandXq22.1Start101,098,188bp[1]
End101,166,126bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for CENPI
Genomic location for CENPI
BandX|X E3Start133,208,833bp[2]
End133,263,388bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • ventricular zone

  • gonad

  • ganglionic eminence

  • testicle

  • stromal cell of endometrium

  • smooth muscle tissue

  • bone marrow

  • rectum

  • trabecular bone
Top expressed in
  • hand

  • tail of embryo

  • dermis

  • genital tubercle

  • otic vesicle

  • abdominal wall

  • endothelial cell of lymphatic vessel

  • ventricular zone

  • renal corpuscle

  • spermatid
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2491

102920

Ensembl

ENSG00000102384

ENSMUSG00000031262

UniProt

Q92674

Q8K1K4

RefSeq (mRNA)

NM_006733
NM_001318521
NM_001318523
NM_001386188

NM_145924
NM_001305631

RefSeq (protein)

NP_001305450
NP_001305452
NP_006724

NP_001292560
NP_666036

Location (UCSC)Chr X: 101.1 – 101.17 MbChr X: 133.21 – 133.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centromere protein I is aprotein that in humans is encoded by theCENPIgene.[5][6]

Function

[edit]

The product of this gene is involved in the response of gonadal tissues tofollicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development andgametogenesis.[6] CENPI is a target gene of thetranscription factorE2F.[7] Additionally, CENPI expression is increased inbreast cancer and this has been shown to causechromosome instability in breast cancer cells.[7]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000102384 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000031262 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres".Nature Cell Biology.8 (5):446–57.doi:10.1038/ncb1396.PMID 16622420.S2CID 26974412.
  6. ^ab"Entrez Gene: CENPI centromere protein I".
  7. ^abThangavelu PU, Lin CY, Vaidyanathan S, Nguyen TH, Dray E, Duijf PH (September 2017)."CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer".Oncotarget.8 (37):62167–62182.doi:10.18632/oncotarget.19131.PMC 5617495.PMID 28977935.

Further reading

[edit]

External links

[edit]
Basic
concepts
Types
Processes
and evolution
Structures
Histone
Centromere
See also


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