CCAAT/enhancer-binding protein gamma (C/EBPγ) is aprotein that in humans is encoded by theCEBPGgene.[5][6] This gene has nointrons.
TheC/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain thebZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and aleucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins,C/EBPα,C/EBPβ, C/EBPγ,C/EBPδ,C/EBPζ, andC/EBPε, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate withFos to bind the positive regulatory element-I (PRE-I) enhancer elements.[6][7]
^Davydov IV, Bohmann D, Krammer PH, Li-Weber M (August 1995). "Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter".Gene.161 (2):271–275.doi:10.1016/0378-1119(95)00271-7.PMID7665092.
Lundgren M, Larsson C, Femino A, Xu M, Stavnezer J, Severinson E (October 1994). "Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site".Journal of Immunology.153 (7):2983–2995.doi:10.4049/jimmunol.153.7.2983.PMID8089482.S2CID24982598.
Hattori T, Ohoka N, Inoue Y, Hayashi H, Onozaki K (March 2003). "C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer".Oncogene.22 (9):1273–1280.doi:10.1038/sj.onc.1206204.PMID12618752.S2CID1351748.
