The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[7]
CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.[8]
One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.[9]
Function ofCEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.[10]
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Wood S, Schertzer M, Yaremko ML (1995). "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p".Cytogenetics and Cell Genetics.70 (3–4):188–191.doi:10.1159/000134030.PMID7789168.
Cleutjens CB, van Eekelen CC, van Dekken H, Smit EM, Hagemeijer A, Wagner MJ, et al. (May 1993). "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization".Genomics.16 (2):520–523.doi:10.1006/geno.1993.1220.PMID8314590.
Xia C, Cheshire JK, Patel H, Woo P (December 1997). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes".The International Journal of Biochemistry & Cell Biology.29 (12):1525–1539.doi:10.1016/S1357-2725(97)00083-6.PMID9570146.
Angeloni D, Lee JD, Johnson BE, Teh BT, Dean M, Lerman MI, et al. (December 2001). "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2".Molecular and Cellular Probes.15 (6):395–397.doi:10.1006/mcpr.2001.0377.hdl:11382/3170.PMID11851384.S2CID8215328.
Milde-Langosch K, Löning T, Bamberger AM (May 2003). "Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins".Breast Cancer Research and Treatment.79 (2):175–185.doi:10.1023/A:1023929504884.PMID12825852.S2CID45020949.
Chen YW, Hubal MJ, Hoffman EP, Thompson PD, Clarkson PM (December 2003). "Molecular responses of human muscle to eccentric exercise".Journal of Applied Physiology.95 (6):2485–2494.doi:10.1152/japplphysiol.01161.2002.PMID12937035.S2CID9817319.
Li R, Strohmeyer R, Liang Z, Lue LF, Rogers J (September 2004). "CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease".Neurobiology of Aging.25 (8):991–999.doi:10.1016/j.neurobiolaging.2003.10.016.PMID15212823.S2CID54232508.
Sivko GS, Sanford DC, Dearth LD, Tang D, DeWille JW (November 2004). "CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control".Journal of Cellular Biochemistry.93 (4):844–856.doi:10.1002/jcb.20224.PMID15389878.S2CID31572695.
