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CEACAM6

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From Wikipedia, the free encyclopedia

Mammalian protein found in Homo sapiens

CEACAM6

Available structures

PDB

Human UniProt search:PDBe RCSB

List of PDB id codes
4WTZ,4WHC,4YIQ,4Y8A

Identifiers

Aliases

CEACAM6, CD66c, CEAL, NCA, carcinoembryonic antigen related cell adhesion molecule 6, CEA cell adhesion molecule 6

External IDs

OMIM:163980;HomoloGene:130505;GeneCards:CEACAM6;OMA:CEACAM6 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.2	Start	41,750,977bp^[1]
Band	19q13.2	End	41,772,211bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pancreatic ductal cell

palpebral conjunctiva

nasal epithelium

mucosa of colon

mucosa of sigmoid colon

lower lobe of lung

mucosa of pharynx

epithelium of bronchus

trabecular bone

bronchial epithelial cell

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding identical protein binding protein heterodimerization activity
Cellular component	plasma membrane integral component of plasma membrane membrane extracellular space azurophil granule membrane cell surface apical plasma membrane anchored component of membrane
Biological process	cell-cell signaling leukocyte migration positive regulation of cell population proliferation positive regulation of cell migration neutrophil degranulation homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules signal transduction positive regulation of heterotypic cell-cell adhesion positive regulation of endothelial cell-matrix adhesion via fibronectin negative regulation of anoikis apoptotic process cell adhesion
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


4680


n/a

Ensembl


ENSG00000086548


n/a

UniProt


P40199


n/a

RefSeq (mRNA)


NM_002483


n/a

RefSeq (protein)


NP_002474


n/a

Location (UCSC)

Chr 19: 41.75 – 41.77 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) also known asCD66c (Cluster ofDifferentiation66c), is a member of thecarcinoembryonic antigen (CEA)gene family..^[3]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000086548 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)".

Oikawa S, Inuzuka C, Kuroki M, et al. (1991)."A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains".J. Biol. Chem.266 (13):7995–8001.doi:10.1016/S0021-9258(18)92930-3.PMID 2022629.
Haus O, Noworolska A, Laskowski M, et al. (1990). "Prognostic significance of secondary cytogenetic changes and nonspecific cross-reacting antigen (NCA) in patients with Ph-positive chronic myeloid leukemia".Exp. Mol. Pathol.52 (2):235–42.doi:10.1016/0014-4800(90)90008-2.PMID 2332039.
Hefta SA, Paxton RJ, Shively JE (1990)."Sequence and glycosylation site identity of two distinct glycoforms of nonspecific cross-reacting antigen as demonstrated by sequence analysis and fast atom bombardment mass spectrometry".J. Biol. Chem.265 (15):8618–26.doi:10.1016/S0021-9258(19)38932-X.PMID 2341397.
Inazawa J, Abe T, Inoue K, et al. (1990). "Regional assignment of nonspecific cross-reacting antigen (NCA) of the CEA gene family to chromosome 19 at band q13.2".Cytogenet. Cell Genet.52 (1–2):28–31.doi:10.1159/000132833.PMID 2612212.
Neumaier M, Zimmermann W, Shively L, et al. (1988)."Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen".J. Biol. Chem.263 (7):3202–7.doi:10.1016/S0021-9258(18)69055-6.PMID 2830274.
Kuroki M, Kuroki M, Moore GE, et al. (1988)."The molecular heterogeneity of nonspecific cross-reacting antigen synthesized by tumor cells and granulocytes".Jpn. J. Cancer Res.79 (1):82–90.doi:10.1111/j.1349-7006.1988.tb00014.x.PMC 5907763.PMID 3128509.
Barnett T, Goebel SJ, Nothdurft MA, Elting JJ (1989). "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains".Genomics.3 (1):59–66.doi:10.1016/0888-7543(88)90160-7.PMID 3220478.
Tawaragi Y, Oikawa S, Matsuoka Y, et al. (1988). "Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence".Biochem. Biophys. Res. Commun.150 (1):89–96.Bibcode:1988BBRC..150...89T.doi:10.1016/0006-291X(88)90490-1.PMID 3337731.
Noworolska A, Harłozińska-Szmyrka A, Richter R (1986). "Distribution of surface nonspecific cross-reacting antigen and influence of proteolytic enzymes on this antigen in myeloid cell series".Cancer Detect. Prev.9 (3–4):365–71.PMID 3527416.
Oikawa S, Kosaki G, Nakazato H (1987). "Molecular cloning of a gene for a member of carcinoembryonic antigen (CEA) gene family; signal peptide and N-terminal domain sequences of nonspecific crossreacting antigen (NCA)".Biochem. Biophys. Res. Commun.146 (2):464–9.Bibcode:1987BBRC..146..464O.doi:10.1016/0006-291X(87)90552-3.PMID 3619891.
Watt SM, Fawcett J, Murdoch SJ, et al. (1994)."CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant".Blood.84 (1):200–10.doi:10.1182/blood.V84.1.200.200.PMID 8018919.
Honda Y, Egawa K, Kuroki M, Ono T (1997). "Hair cycle-dependent expression of a nonspecific cross reacting antigen (NCA)-50/90-like molecule on follicular keratinocytes".Arch. Dermatol. Res.289 (8):457–65.doi:10.1007/s004030050221.PMID 9266023.S2CID 8163767.
Schölzel S, Zimmermann W, Schwarzkopf G, et al. (2000)."Carcinoembryonic Antigen Family Members CEACAM6 and CEACAM7 Are Differentially Expressed in Normal Tissues and Oppositely Deregulated in Hyperplastic Colorectal Polyps and Early Adenomas".Am. J. Pathol.156 (2):595–605.doi:10.1016/S0002-9440(10)64764-5.PMC 1850034.PMID 10666389.
Oikawa S, Sugiyama M, Kuroki M, et al. (2001). "Extracellular N-domain alone can mediate specific heterophilic adhesion between members of the carcinoembryonic antigen family, CEACAM6 and CEACAM8".Biochem. Biophys. Res. Commun.278 (3):564–8.doi:10.1006/bbrc.2000.3858.PMID 11095950.
Ilantzis C, DeMarte L, Screaton RA, Stanners CP (2002)."Deregulated Expression of the Human Tumor Marker CEA and CEA Family Member CEACAM6 Disrupts Tissue Architecture and Blocks Colonocyte Differentiation".Neoplasia.4 (2):151–63.doi:10.1038/sj.neo.7900201.PMC 1550325.PMID 11896570.
Singer BB, Scheffrahn I, Heymann R, et al. (2002)."Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes".J. Immunol.168 (10):5139–46.doi:10.4049/jimmunol.168.10.5139.PMID 11994468.
Skubitz KM, Campbell KD, Skubitz AP (2002)."Synthetic peptides from the N-domains of CEACAMs activate neutrophils".J. Pept. Res.58 (6):515–26.doi:10.1034/j.1399-3011.2001.00931.x.PMC 7162001.PMID 12005421.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Taheri M, Saragovi HU, Stanners CP (2003)."The adhesion and differentiation-inhibitory activities of the immunoglobulin superfamily member, carcinoembryonic antigen, can be independently blocked".J. Biol. Chem.278 (17):14632–9.doi:10.1074/jbc.M212500200.PMID 12571231.
Duxbury MS, Ito H, Zinner MJ, et al. (2004)."CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells".Oncogene.23 (2):465–73.doi:10.1038/sj.onc.1207036.PMID 14724575.

External links

[edit]

HumanCEACAM6 genome location andCEACAM6 gene details page in theUCSC Genome Browser.
CEACAM6+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

v t e Proteins:clusters of differentiation (see alsolist of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 -CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 -CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350