Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known asCD66d (Cluster ofDifferentiation66d), is a member of thecarcinoembryonic antigen (CEA)gene family..[3]
This gene encodes a member of the family ofcarcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterialpathogens to bind and invade host cells. The encodedtransmembrane protein directsphagocytosis of several bacterial species that is dependent on the smallGTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]
^CEACAM3: an innate immune receptor directed against human-restricted bacterial pathogens. Pils S, Gerrard DT, Meyer A, Hauck CR. Int J Med Microbiol. 2008 Oct;298(7-8):553-60.
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