Movatterモバイル変換

[0]ホーム

Jump to content

CDH10

Edit links

From Wikipedia, the free encyclopedia

Protein-coding gene in humans

CDH10

Identifiers

Aliases

CDH10, cadherin 10

External IDs

OMIM:604555;MGI:107436;HomoloGene:68530;GeneCards:CDH10;OMA:CDH10 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5p14.2-p14.1	Start	24,487,100bp^[1]
Band	5p14.2-p14.1	End	24,644,978bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15 A2\|15 8.2 cM	Start	18,819,033bp^[2]
Band	15 A2\|15 8.2 cM	End	19,014,322bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Brodmann area 23

middle temporal gyrus

Brodmann area 46

orbitofrontal cortex

superior frontal gyrus

cerebellar hemisphere

entorhinal cortex

right hemisphere of cerebellum

prefrontal cortex

dorsolateral prefrontal cortex

Top expressed in

Subplate

barrel cortex

prefrontal cortex

Region I of hippocampus proper

facial motor nucleus

ventral tegmental area

anterior horn of spinal cord

primary motor cortex

dorsal tegmental nucleus

deep cerebellar nuclei

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	calcium ion binding metal ion binding cytoskeletal protein binding protein homodimerization activity cadherin binding
Cellular component	integral component of membrane plasma membrane membrane glutamatergic synapse GABA-ergic synapse integral component of presynaptic active zone membrane integral component of postsynaptic specialization membrane cell surface catenin complex
Biological process	cell adhesion adherens junction organization homophilic cell adhesion via plasma membrane adhesion molecules cell-cell adhesion cell-cell junction assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin cell morphogenesis
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


1008


320873

Ensembl


ENSG00000040731


ENSMUSG00000022321

UniProt


Q9Y6N8


P70408

RefSeq (mRNA)


NM_001190450 NM_006727 NM_001317222 NM_001317224 NM_001362460


NM_009865 NM_001316758

RefSeq (protein)


NP_001304151 NP_001304153 NP_006718 NP_001349389 NP_001304153.1


NP_001303687 NP_033995

Location (UCSC)

Chr 5: 24.49 – 24.64 Mb

Chr 15: 18.82 – 19.01 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cadherin 10 is aprotein that in humans is encoded by theCDH10gene.^[5]^[6]

Clinical significance

[edit]

An association withautism has been suggested.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000040731 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000022321 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: cadherin 10".
^Suzuki S, Sano K, Tanihara H (April 1991)."Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue".Cell Regul.2 (4):261–70.doi:10.1091/mbc.2.4.261.PMC 361775.PMID 2059658.
^Wang K, Zhang H, Ma D, et al. (May 2009)."Common genetic variants on 5p14.1 associate with autism spectrum disorders".Nature.459 (7246):528–33.Bibcode:2009Natur.459..528W.doi:10.1038/nature07999.PMC 2943511.PMID 19404256.

External links

[edit]

HumanCDH10 genome location andCDH10 gene details page in theUCSC Genome Browser.

Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome".Cell.122 (6):957–68.doi:10.1016/j.cell.2005.08.029.hdl:11858/00-001M-0000-0010-8592-0.PMID 16169070.S2CID 8235923.
Rose JE, Behm FM, Drgon T, et al. (2010)."Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score".Mol. Med.16 (7–8):247–53.doi:10.2119/molmed.2009.00159.PMC 2896464.PMID 20379614.
Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2000)."Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins".Biochem. J.349 (Pt 1):159–67.doi:10.1042/0264-6021:3490159.PMC 1221133.PMID 10861224.
Wang K, Zhang H, Ma D, et al. (2009)."Common genetic variants on 5p14.1 associate with autism spectrum disorders".Nature.459 (7246):528–33.Bibcode:2009Natur.459..528W.doi:10.1038/nature07999.PMC 2943511.PMID 19404256.
Potkin SG, Guffanti G, Lakatos A, et al. (2009)."Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease".PLOS ONE.4 (8) e6501.Bibcode:2009PLoSO...4.6501P.doi:10.1371/journal.pone.0006501.PMC 2719581.PMID 19668339.
Gil OD, Needleman L, Huntley GW (2002). "Developmental patterns of cadherin expression and localization in relation to compartmentalized thalamocortical terminations in rat barrel cortex".J. Comp. Neurol.453 (4):372–88.doi:10.1002/cne.10424.PMID 12389209.S2CID 25610258.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16 (1):55–65.doi:10.1101/gr.4039406.PMC 1356129.PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Kools P, Vanhalst K, Van den Eynde E, van Roy F (1999)."The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14".FEBS Lett.452 (3):328–34.doi:10.1016/S0014-5793(99)00672-9.PMID 10386616.S2CID 44714251.
Hillier LD, Lennon G, Becker M, et al. (1996)."Generation and analysis of 280,000 human expressed sequence tags".Genome Res.6 (9):807–28.doi:10.1101/gr.6.9.807.PMID 8889549.
Ali J, Liao F, Martens E, Muller WA (1997). "Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion".Microcirculation.4 (2):267–77.doi:10.3109/10739689709146790.PMID 9219219.S2CID 21501093.
Ma D, Salyakina D, Jaworski JM, et al. (2009)."A genome-wide association study of autism reveals a common novel risk locus at 5p14.1".Ann. Hum. Genet.73 (Pt 3):263–73.doi:10.1111/j.1469-1809.2009.00523.x.PMC 2918410.PMID 19456320.
Hülsken J, Birchmeier W, Behrens J (1994)."E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton".J. Cell Biol.127 (6 Pt 2):2061–9.doi:10.1083/jcb.127.6.2061.PMC 2120290.PMID 7806582.

Membrane proteins:cell adhesion molecules

Calcium-independent

IgSF CAM	N-CAM (Myelin protein zero) ICAM (1,5) VCAM-1 PE-CAM L1 family L1-CAM NRCAM NFASC CHL1 Nectin PVRL1 PVRL2 PVRL3 CADM1 CADM3 CD155
Integrins	LFA-1 (CD11a+CD18) Integrin alphaXbeta2 (CD11c+CD18) Macrophage-1 antigen (CD11b+CD18) VLA-4 (CD49d+CD29) Glycoprotein IIb/IIIa (ITGA2B+ITGB3)

Calcium-dependent

Cadherins

Classical	CDH1 CDH2 CDH3
Desmosomal	Desmoglein (DSG1,DSG2,DSG3,DSG4) Desmocollin (DSC1,DSC2,DSC3)
Protocadherin	PCDH1 PCDH15 PCDH19
Unconventional/ungrouped	T-cadherin CDH4 CDH5 CDH6 CDH8 CDH11 CDH12 CDH15 CDH16 CDH17 CDH9 CDH10