Cyclin dependent kinase 13 is anenzyme that in humans is encoded by theCDK13gene.[5][6]
The protein encoded by this gene is a member of thecyclin-dependentserine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches incell cycle control. Some of the cell cycle control kinases are able tophosphorylate proteins that are important for cell differentiation andapoptosis, thus provide connections between cell proliferation, differentiation, and apoptosis. Proteins of this family may also be involved in non-cell cycle-related functions, such asneurocytoskeleton dynamics. The exact function of this protein has not yet been determined. It has unusually largeN- andC-termini and is ubiquitously expressed in many tissues. Twoalternatively spliced variants are described.[6]
Mutations inCDK13 causeCDK13-related disorder. A 2017 study of children with raredevelopmental disorders found 11 children in the United Kingdom who had a fault in theirCDK13 gene.[7] This fault affected the children's communication and language skills as well as causing learning difficulties.[8]
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