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CDC2L1

From Wikipedia, the free encyclopedia
Protein-coding gene in humans
CDK11B
Identifiers
AliasesCDK11B, CDC2L1, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, PITSLREA, PK58, p58, p58CDC2L1, p58CLK-1, cyclin-dependent kinase 11B, cyclin dependent kinase 11B
External IDsOMIM:176873;MGI:88353;HomoloGene:137644;GeneCards:CDK11B;OMA:CDK11B - orthologs
EC number2.7.11.22
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CDK11B
Genomic location for CDK11B
Band1p36.33Start1,635,225bp[1]
End1,659,012bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for CDK11B
Genomic location for CDK11B
Band4 E2|4 86.73 cMStart155,624,854bp[2]
End155,649,938bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • gastrocnemius muscle

  • gastric mucosa

  • left testis

  • muscle layer of sigmoid colon

  • right testis

  • granulocyte

  • mucosa of transverse colon

  • muscle of thigh

  • right lung
Top expressed in
  • granulocyte

  • tail of embryo

  • neural layer of retina

  • saccule

  • genital tubercle

  • otic placode

  • ventricular zone

  • otic vesicle

  • epiblast

  • body of femur
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

984

12537

Ensembl

ENSG00000248333

ENSMUSG00000029062

UniProt

P21127

P24788

RefSeq (mRNA)
NM_001291345
NM_001787
NM_033486
NM_033487
NM_033488

NM_033489
NM_033490
NM_033492
NM_033493

NM_007661
NM_001347308
NM_001355567
NM_001355568
NM_001355569

RefSeq (protein)
NP_001278274
NP_001778
NP_277021
NP_277022
NP_277024

NP_277025

NP_001334237
NP_031687
NP_001342496
NP_001342497
NP_001342498

Location (UCSC)Chr 1: 1.64 – 1.66 MbChr 4: 155.62 – 155.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PITSLRE serine/threonine-protein kinase CDC2L1 is anenzyme that in humans is encoded by theCDK11Bgene.[5][6][7]

This gene encodes a member of the p34Cdc2 proteinkinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity toCDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplifiedMYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported.[7]

Interactions

[edit]

CDC2L1 has been shown tointeract withCyclin D3.[8]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000248333 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000029062 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Eipers PG, Barnoski BL, Han J, Carroll AJ, Kidd VJ (Mar 1992). "Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1p36 and a highly related sequence to chromosome 15".Genomics.11 (3):621–9.doi:10.1016/0888-7543(91)90069-Q.PMID 1774066.
  6. ^Mikolajczyk M, Shi J, Vaillancourt RR, Sachs NA, Nelson M (Sep 2003). "The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM".Biochem. Biophys. Res. Commun.310 (1):14–8.doi:10.1016/j.bbrc.2003.08.116.PMID 14511641.
  7. ^ab"Entrez Gene: CDC2L1 cell division cycle 2-like 1 (PITSLRE proteins)".
  8. ^Zhang, Songwen; Cai Mingmei; Zhang Si; Xu Songli; Chen She; Chen Xiaoning; Chen Chun; Gu Jianxin (Sep 2002)."Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3".J. Biol. Chem.277 (38):35314–22.doi:10.1074/jbc.M202179200.ISSN 0021-9258.PMID 12082095.

Further reading

[edit]

External links

[edit]
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Activity
Regulation
Classification
Kinetics
Types
Portal:


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