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CD98

From Wikipedia, the free encyclopedia

Family of protein complexes
solute carrier family 3 member 2 (activators of dibasic and neutral amino acid transport)
Identifiers
SymbolSLC3A2
Alt. symbolsMDU1, 4T2HC, 4F2, NACAE, CD98
NCBI gene6520
HGNC11026
OMIM158070
RefSeqNM_001013251
UniProtP08195
Other data
LocusChr. 11q12-q22
Search for
StructuresSwiss-model
DomainsInterPro
solute carrier family 7 member 5 (cationic amino acid transporter, y+ system)
Identifiers
SymbolSLC7A5
Alt. symbolsLAT1, E16, D16S469E, MPE16, CD98
NCBI gene8140
HGNC11063
OMIM600182
RefSeqNM_003486
UniProtQ01650
Other data
LocusChr. 16q24.3
Search for
StructuresSwiss-model
DomainsInterPro

CD98 is aglycoprotein[1][2] that is a heterodimer composed ofSLC3A2 andSLC7A5 that forms thelarge neutral amino acid transporter (LAT1). LAT1 is a heterodimericmembrane transport protein that preferentially transportsbranched-chain (valine,leucine,isoleucine) andaromatic (tryptophan,tyrosine,phenylalanine)amino acids.[3] LAT is highly expressed in braincapillaries (which form theblood–brain barrier) relative to other tissues.[3]

A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:

  • 4F2hc/CD98 heavy subunit protein encoded by theSLC3A2 gene[4]
  • CD98 light subunit protein encoded by theSLC7A5 gene[5]

See also

[edit]

References

[edit]
  1. ^Kucharzik T, Lugering A, Yan Y, Driss A, Charrier L, Sitaraman S, Merlin D (2005). "Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation".Lab. Invest.85 (7):932–41.doi:10.1038/labinvest.3700289.PMID 15880135.S2CID 19733993.
  2. ^Lemaître G, Gonnet F, Vaigot P, Gidrol X, Martin MT, Tortajada J, Waksman G (2005). "CD98, a novel marker of transient amplifying human keratinocytes".Proteomics.5 (14):3637–45.doi:10.1002/pmic.200401224.PMID 16097038.S2CID 31954787.
  3. ^abBoado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM (1999)."Selective expression of the large neutral amino acid transporter at the blood–brain barrier".Proc. Natl. Acad. Sci. U.S.A.96 (21):12079–84.Bibcode:1999PNAS...9612079B.doi:10.1073/pnas.96.21.12079.PMC 18415.PMID 10518579.
  4. ^Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters".Pflügers Arch.447 (5):490–494.doi:10.1007/s00424-003-1062-7.PMID 14770309.S2CID 25808108.
  5. ^Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004)."CATs and HATs: the SLC7 family of amino acid transporters"(PDF).Pflügers Arch.447 (5):532–542.doi:10.1007/s00424-003-1086-z.PMID 14770310.S2CID 11670040.

External links

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SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)


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